|Related Categories||2D Cell Culture, 3D Matricies for Stem Cell Biology, Adhesion, Attachment, and Matrix Factors, Adhesion, Attachment, and Matrix Factors for Stem Cell Expansion, Apoptosis and Cell Cycle,|
|concentration||1 mg/mL in Tris buffered NaCl|
|surface coverage||1‑2 μg/cm2|
|suitability||suitable for cell culture|
|shipped in||dry ice|
|Gene Information||mouse ... Lama1(16772), Lama3(16774), Lama5(16776), Lamb1-1(16777), Lamc1(226519), Lamc2(16782)|
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Laminin supports growth and differentiation of many cell types including epithelial, endothelial, neural, muscle, and liver cells.
Recommended for use as a cell culture substratum at 1-2 μg/cm2. Optimal concentration depends on cell type as well as the application or research objectives.
Laminin, an extracellular matrix (ECM) multidomain trimeric glycoprotein, is the major non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. It was initially isolated from mouse Engelbreth-Holm-Swarm (EHS) tumor (laminin-1). Laminin proteins are integral components of structural scaffolding in animal tissues. Laminins associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystrogylcan glycoprotein complex and Lutheran blood group glycoprotein.
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Certificate of Analysis
Certificate of Origin
Three-dimensional (3D) extracellular matrix-based cell culture systems are being used as research tools for understanding normal and disease systems, and for drug screening in vitro. The extracellula...
BioFiles 2008, 3.8, 16.
Keywords: Adhesion, Angiogenesis, Biomaterials, Cancer, Cell biology, Cell culture, Clinical, Gene expression, Genetic, Genetics, Genomics, Growth factors, Hormones, Molecular biology, Morphogenesis
Q1) Can I coat laminin on top of poly-L-lysine for better adherence? A1) When coating coverslips or slides for use with neural stem cells (neurospheres) the following procedure is used. Precoat the c...
BioFiles 2008, 3.8, 11.
Keywords: PAGE, SDS PAGE
Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth (PHD) fragment.1 Laminin chains are designated A (molecular weight 400kDa), B1 (molecular weight...
BioFiles 2008, 3.8, 11.
Keywords: Adhesion, Cell culture
Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation
Establishment of a cell line from the EHS tumor: biosynthesis of basement membrane constituents and characterization of a hybrid proteoglycan containing heparan and chondroitin sulfate chains Danielson KG, et al. Matrix 2, 22-35, (1992)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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