L2020 Sigma

Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane

1 mg/mL in Tris buffered NaCl, sterile-filtered, BioReagent, suitable for cell culture

Description

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Application

Laminin supports growth and differentiation of many cell types including epithelial, endothelial, neural, muscle, and liver cells.

Recommended for use as a cell culture substratum at 1-2 μg/cm2. Optimal concentration depends on cell type as well as the application or research objectives.

General description

Laminin, an extracellular matrix (ECM) multidomain trimeric glycoprotein, is the major non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. It was initially isolated from mouse Engelbreth-Holm-Swarm (EHS) tumor (laminin-1). Laminin proteins are integral components of structural scaffolding in animal tissues. Laminins associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystrogylcan glycoprotein complex and Lutheran blood group glycoprotein.

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