LFM-A13
≥98% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym:
α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide,
(2Z)
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CAS Number 244240-24-2
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Empirical Formula (Hill Notation) C11H8Br2N2O2
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Molecular Weight 360.00
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MDL number MFCD09878279
Properties
| Related Categories | Bioactive Small Molecules, Bruton′s tyrosine kinase (BTK), Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥19 mg/mL |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases
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