|Related Categories||Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,|
|solubility||DMSO: soluble50 mg/mL|
human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)|
rat ... Hrh1(24448)
Non-sedating histamine H1-receptor antagonist.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. L9664.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Baroody, F.M. and Naclerio, R.M. AMA Arch. Pathol. 55 Suppl. 64, 17, (2000)
The antihistamines clemastine and desloratadine inhibit STAT3 and c-Myc activities and induce apoptosis in cutaneous T-cell lymphoma cell lines. Döbbeling U, Waeckerle-Men Y, Zabel F, et al. Exp. Dermatol. 22(2), 119-24, (2013)
A comparative study of loratadine syrup and cyproheptadine HCL solution for treating perennial allergic rhinitis in Taiwanese children aged 2-12 years. Wu KG, Li TH, Wang TY, et al. Int. J. Immunopathol. Pharmacol. 25(1), 231-7, (2012)
Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation. Magerl M, Pisarevskaja D, Staubach P, et al. Br. J. Dermatol. 166(5), 1095-9, (2012)
Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study. Soares DN, Valinoti AC, Pierro VS, et al. Eur. Arch. Paediatr. Dent. 13(5), 261-5, (2012)
Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. Duke JD, Han X, Wang Z, et al. PLoS Comput. Biol. 8(8), e1002614, (2012)
Efficacy of prophylactic treatment with montelukast and montelukast plus add-on loratadine for seasonal allergic rhinitis. Yamamoto H, Yamada T, Sakashita M, et al. Allergy Asthma Proc. 33(2), e17-22, (2012)
Molecularly imprinted nano particles combined with miniaturized homogenous liquid-liquid extraction for the selective extraction of loratadine in plasma and urine samples followed by high performance liquid chromatography-photo diode array detection. Ebrahimzadeh H, Molaei K, Asgharinezhad AA, et al. Anal. Chim. Acta 767, 155-62, (2013)
Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours. Purohit A, Melac M, Pauli G, et al. Ann. Allergy Asthma Immunol. 92(6), 635-40, (2004)
Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study. Wang P, Liang YZ, Chen BM, et al. J. Pharm. Biomed. Anal. 43(4), 1519-25, (2007)
Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary to NMDA receptor antagonism with a low dose of amantadine. Deep P, Dagher A, Sadikot A, et al. Synapse 34(4), 313-8, (1999)
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