MET (956-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
DOWNLOAD MSDS (PDF)Synonym: HGFR, RCCP2
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Properties
| Related Categories | Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, |
| recombinant | expressed in baculovirus infected Sf9 cells |
| grade | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| activity | 37-55 nmol/min·mg |
| mol wt | mol wt ~81 kDa |
| shipped in | dry ice |
Description
Biochem/physiol Actions
MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulfide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovariancancers and has been shown to be involved in tumor cell migration and invasion.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
Price and Availability
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