|Related Categories||Alkaloid, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,|
|biological source||from Capsicum sp.|
human ... CYP1A2(1544), TRPV1(7442)|
rat ... Trpv1(83810), Trpv4(66026)
Live Chat and Frequently Asked Questions are available for this Product.
Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.
Certificate of Analysis
Certificate of Origin
|Symbol||GHS05, GHS06, GHS08|
|Precautionary statements||P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25-37/38-41-42/43|
|Safety Statements (Europe)||22-26-28-36/39-45|
|RIDADR||UN 2811 6.1/PG 2|
|Flash Point(F)||235.4 °F|
|Flash Point(C)||113 °C|
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors. José M. Entrena et al Psychopharmacology 205, 21-33, (2009)
Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice. Tasuku Akiyama et al J. Pharmacol. Exp. Ther. 329, 945-51, (2009)
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. Swanson, DM., et al. J. Med. Chem. 48, 1857-1872, (2005)
Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. Mutasem O Taha et al J. Med. Chem. 51, 6478-94, (2008)
Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Yoshihisa Ogawa et al Bioorg. Med. Chem. Lett. 20, 2111-4, (2010)
Arctander, 567 / FT-IR 2 (2), 2985:C / FT-NMR 1 (2), 1378:C / Fenaroli, 364 / RegBook 1 (2), 2009:M / Sax 6, 629 / Structure Index 1, 320:E:8
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?