Capsaicin

Papers

Plasticity Of Nodose Ganglion Neurons After Capsaicin- And Vagotomy-induced Nerve Damage In Adult Rats. Ryu, V., et al. Neuroscience 167, 1227-38, (2010)

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Recovery Of Viscerosensory Innervation From The Dorsal Root Ganglia Of The Adult Rat Following Capsaicin-induced Injury. Gallaher, Z.R., et al. J. Comp. Neurol. 518, 3529-40, (2010)

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Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. Christina Nassenstein et al J. Physiol. 586, 1595-604, (2008)

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Properties of the inner pore region of TRPV1 channels revealed by block with quaternary ammoniums. Andrés Jara-Oseguera et al J. Gen. Physiol. 132, 547-62, (2008)

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Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors. José M. Entrena et al Psychopharmacology 205, 21-33, (2009)

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Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice. Tasuku Akiyama et al J. Pharmacol. Exp. Ther. 329, 945-51, (2009)

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Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function. Jose Michel et al PLoS ONE 6, DOI: 10.1371/journal.pone.0017420, (2011)

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Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. Swanson, DM., et al. J. Med. Chem. 48, 1857-1872, (2005)

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Expanding the ChemGPS chemical space with natural products. Josefin Larsson et al J. Nat. Prod. 68, 985-91, (2005)

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Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. E Fontana et al Curr. Drug Metab. 6, 413-54, (2005)

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Sensing with TRP channels. Thomas Voets et al Nat. Chem. Biol. 1, 85-92, (2005)

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Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety. Giovanni Appendino et al Bioorg. Med. Chem. Lett. 17, 132-5, (2007)

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Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. Mutasem O Taha et al J. Med. Chem. 51, 6478-94, (2008)

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Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. Giovanni Appendino et al J. Med. Chem. 52, 3001-9, (2009)

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Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Hyun-Kyung Choi et al Bioorg. Med. Chem. 17, 690-8, (2009)

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Synthesis and antinociceptive activity of capsinoid derivatives. G-J He et al Eur. J. Med. Chem. 44, 3345-9, (2009)

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Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Yoshihisa Ogawa et al Bioorg. Med. Chem. Lett. 20, 2111-4, (2010)

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists. Natalie A Hawryluk et al Bioorg. Med. Chem. Lett. 20, 7137-41, (2010)

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Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene. Giovanni Appendino et al Bioorg. Med. Chem. Lett. 20, 97-9, (2010)

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In vitro TRPV1 activity of piperine derived amides. E. A. Correa, et al., Bioorg. Med. Chem. 18, 3299-3306, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Enrico Morera et al Bioorg. Med. Chem. Lett. 22, 1674-7, (2012)

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Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Holzer, P. Neuroscience 24, 739-768, (1988)

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Sensory neuron-specific actions of capsaicin: mechanisms and applications. Bevan, S., and Szolcsanyi, J. Trends Pharmacol. Sci. 11, 330-333, (1990)

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Merck 14,1768

Beil. 13,IV,2588

Arctander, 567 / FT-IR 2 (2), 2985:C / FT-NMR 1 (2), 1378:C / Fenaroli, 364 / RegBook 1 (2), 2009:M / Sax 6, 629 / Structure Index 1, 320:E:8