Mevastatin

Papers

The importance of N-linked glycoproteins and dolichol phosphate synthesis for fusion of L6 myoblasts. Jamieson, J.C. Biochem. Cell Biol. 70, 408, (1992)

---

Studies on the effect of mevinolin (lovastatin) and mevastatin (compactin) on the fusion of L6 myoblasts. Belo, R.S., et al. Mol. Cell Biochem. 126, 159, (1993)

---

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. Brown, M.S., et al. J. Biol. Chem. 253, 1121, (1978)

---

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. Laufs, U., Liao, J.K. J. Biol. Chem. 273, 24266, (1998)

---

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cellsin vitro by inhibiting the mevalonate pathway. Shipman, C.M., et al. Cancer Res. 58, 5294-5297, (1998)

---

Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. Coxon, F.P., et al. Mol. Pharmacol. 54, 631, (1998)

---

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Luckman, S.P. J. Bone Miner Res. 13, 581, (1998)

---

Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA). Ramasamy Thilagavathi et al Bioorg. Med. Chem. Lett. 15, 1027-32, (2005)

---

Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

---

Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum. Bruno Pradines et al Antimicrob. Agents Chemother. 51, 2654-5, (2007)

---

Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

---

Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors. Shinnosuke Hosoda et al Bioorg. Med. Chem. Lett. 19, 4228-31, (2009)

---

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Uyen T T Nguyen et al Nat. Chem. Biol. 5, 227-35, (2009)

---

Merck 14,6164

Beil. 18,V,3,145