|Related Categories||Aerobic Glycolysis (the Warburg Effect), Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience,|
|color||off-white to tan|
|solubility||DMSO: >25 mg/mL|
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma Baker, A.F., et al. J. Lab. Clin. Med. 147, 83-90, (2006)
he thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation Welsh, S.J., et al. Mol. Cancer Ther. 2, 235-243, (2003)
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