Synonym: α2-M
MDL number MFCD00130472
Popular Documents: Datasheet (PDF)
| Related Categories | α2-Macroglobulin, A to C, Apoptosis Enzymes, Application Index, Aspartic Protease Inhibitors, |
| product line | BioUltra |
| assay | ≥98% (SDS-PAGE) |
| form | lyophilized powder |
| mol wt | mol wt ~720 kDa (four glycoprotein subunits) |
| composition | Protein, 15-30% biuret |
| storage temp. | −20°C |
| Gene Information | human ... A2M(2) |
Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.
One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Package size based on protein content
Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose
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salt-free, lyophilized powder
Prestained
≥95% (SDS-PAGE), lyophilized powder
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