|Related Categories||α2-Macroglobulin, A to C, Apoptosis Enzymes, Application Index, Aspartic Protease Inhibitors,|
|mol wt||mol wt ~720 kDa (four glycoprotein subunits)|
|composition||Protein, 15-30% biuret|
|Gene Information||human ... A2M(2)|
Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.
Package size based on protein content
Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Gas chromatography
Complement Component C3 Binds To Activated Normal Platelets Without Preceding Proteolytic Activation And Promotes Binding To Complement Receptor 1. Hamad, O.A., et al. J. Immunol. 184, 2686-92, (2010)
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. Qiu, Z., et al. J. Neurochem. 73, 1393-1398, (1999)
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