|Related Categories||1.4.x.x Acting on CH-NH2, 1.x.x.x Oxidoreductases, Analytical and Industrial Enzymes, Biochemicals and Reagents, Cell Biology,|
|recombinant||expressed in baculovirus infected BTI insect cells|
|assay||~2.5 mg per vial|
|shipped in||dry ice|
|Gene Information||human ... MAOB(4129)|
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs. 2
Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. 1
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.
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≥0.05 unit/mg solid
recombinant, expressed in baculovirus infected BTI insect cells
recombinant, expressed in wild-type baculovirus infected BTI insect cells
powder, ≥98% (HPLC)
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|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
While reuptake of catecholamines plays an important role in regulating their synaptic levels, metabolism also contributes significantly to the termination of catecholamine neurotransmission. The rela...
Keywords: Atomic layer deposition, Clinical, Dopamine agents, Metabolism, Metabolites, Neurotransmission, Parkinson Disease
Histamine is a biogenic amine that stimulates multiple histamine receptor types. In mammals, histamine is found within granules of basophils and mast cells (>90% of body stores) and within tuberomamm...
Keywords: Atomic layer deposition, Cardiovascular, Ligands, Metabolism, Methylations, Microwave synthesis, Oxidations
From our library of Related Content, Sigma-Aldrich presents Enzyme Explorer: the most comprehensive source of enzymes, substrates, activators, & inhibitors.
Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
2. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders Binda, C., et al. Nat. Struct. Biol. 9, 22-6, (2001)
Interactions of nitrogencontaining xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors. Kalgutkar, A.S., et al. Chem. Res. Toxicol. 14, 1139-1162, (2001)
The effect of age on the activity and molecular properties of human brain monoamine oxidase Fowler, C., et al. J. Neural Transm. Gen. Sect. 49, 1-20, (1980)
Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for improved antioxidant and antidepressant-like activity. Nagpal K, Singh SK, and Mishra DN Drug Deliv. 19(8), 378-91, (2012)
Comparison of expression pattern of monoamine oxidase A with histopathologic subtypes and tumour grade of renal cell carcinoma. Hodorová I, Rybárová S, Vecanová J, et al. Med. Sci. Monit. 18(12), BR482-6, (2012)
Upregulated mRNA levels of SERT, NET, MAOB, and BDNF in various brain regions of ovariectomized rats exposed to chronic aversive stimuli. Charoenphandhu N, Nuntapornsak A, Wongdee K, et al. Mol. Cell Biochem. 375(1-2), 49-58, (2013)
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity. Nag S, Kettschau G, Heinrich T, et al. Bioorg. Med. Chem. 21(1), 186-95, (2013)
TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression. Arias B, Fabbri C, Gressier F, et al. Neuropsychobiology 67(1), 41-7, (2013)
The influence of R and S configurations of a series of amphetamine derivatives on quantitative structure-activity relationship models. Fresqui MA, Ferreira MM, and Trsic M Anal. Chim. Acta 759, 43-52, (2013)
Pharmaco- and therapygenetic aspects in the treatment of anxiety disorders beyond the serotonergic system: a brief review. Faludi G, Gonda X, Bagdy G, et al. Neuropsychopharmacol. Hung. 14(4), 221-9, (2012)
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Márquez C, Poirier GL, Cordero MI, et al. Transl. Psychiatry 3, e216, (2013)
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors. Pisani L, Barletta M, Soto-Otero R, et al. J. Med. Chem. 56(6), 2651-64, (2013)
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. De Colibus L, Li M, Binda C, et al. Proc. Natl. Acad. Sci. U. S. A. 102(36), 12684-9, (2005)
Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Cesura AM, Gottowik J, Lahm HW, et al. Eur. J. Biochem. 236(3), 996-1002, (1996)
A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. Denney RM, Sharma A, Dave SK, et al. J. Neurochem. 63(3), 843-56, (1994)
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Binda C, Li M, Hubalek F, et al. Proc. Natl. Acad. Sci. U. S. A. 100(17), 9750-5, (2003)
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. Hubálek F, Binda C, Khalil A, et al. J. Biol. Chem. 280(16), 15761-6, (2005)
High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae. Li M, Hubálek F, Newton-Vinson P, et al. Protein Expr. Purif. 24(1), 152-62, (2002)
Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. Son SY, Ma J, Kondou Y, et al. Proc. Natl. Acad. Sci. U. S. A. 105(15), 5739-44, (2008)
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|M7566||Monoamine Oxidase Insect Cell Control, recombinant, expressed in wild-type baculovirus infected BTI insect cells|
|M7316||Monoamine Oxidase A human, recombinant, expressed in baculovirus infected BTI insect cells|
|M1821||Anti-Monoamine Oxidase B antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution|
|M1946||Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit, affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution|
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