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M7693 Sigma

Anti-MTA1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Metastasis-associated Gene, Anti-NuRD-70

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies in Chromatin Remodeling, Antibodies to Most Studied Epigenetic Genes, Antibodies to Remodeling Complex,
species reactivity   human
application(s)   immunoprecipitation: 5-10 μg/mL using extracts of 293T cells
  microarray: suitable
  western blot: 0.5-1 μg/mL using nuclear extracts of MCF7 cells
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 75-80 kDa (doublet)
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MTA1(9112)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 626-641 of human MTA1, conjugated to KLH via an N-terminal added cysteine residue. The immunizing sequence is not present in other members of the family, MTA2 and MTA3.

General description

Metastasis associated 1 (MTA1) is a 80kDa protein which possesses four domains and several interaction motifs. It is made up of 715 amino acid residues.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

Metastasis associated 1 (MTA1) has been shown to be overexpressed in many types of cancers and has an important role in cancer malignancy. It takes part in the DNA repair process. As part of the nuclear remodeling and deacetylation complex (NuRD complex), it associates with deacetylated p53. MTA1 participates as a co-repressor and co-activator for many kinds of genes.

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