• USA Home
  • N0258 - N-Nitrosodiethylamine

EMAIL THIS PAGE TO A FRIEND

N0258 Sigma

N-Nitrosodiethylamine

ISOPAC®

Synonym: Diethylnitrosamine

Purchase

Properties

Related Categories Cancer Research, Carcinogens, Cell Biology More...
bp   177 °C(lit.)
density   0.95 g/mL(lit.)

Description

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Caution

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Packaging

1 g in serum bottle

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Customers Also Viewed

N-<WBR>Nitrosodiethylamine

≥99.0% (GC)

N-<WBR>Nitrosodiethylamine

analytical standard

5000 μg/mL in methanol, analytical standard

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
IA3500000

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Applications, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Error, Events, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Sequences, Substitutions, Transcription, Type

Related Content

Carcinogen Selector - Digestive System - Esophagus

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Esophagus
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Digestive System - Liver

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System - Liver
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Digestive System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Digestive System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System - Liver Endocrine

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Liver Endocrine
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Endocrine System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Reproductive System - Lung

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Reproductive System - Lung
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Reproductive System - Nasal Cavity

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Reproductive System - Nasal Cavity
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Respiratory System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Respiratory System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Constitutive Notch2 signaling induces hepatic tumors in mice. Dill MT, Tornillo L, Fritzius T, et al. Hepatology 57(4), 1607-19, (2013)

Loading...


Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. Hong EJ, Levasseur MP, Dufour CR, et al. Proc. Natl. Acad. Sci. U. S. A. 110(44), 17975-80, (2013)

Loading...


Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. Rappa F, Greco A, Podrini C, et al. PLoS ONE 8(1), e54458, (2013)

Loading...


Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Bertran E, Crosas-Molist E, Sancho P, et al. Hepatology 58(6), 2032-44, (2013)

Loading...


N-nitrosodiethylamine. IARC Monogr. Eval. Carcinog. Risk Chem. Man 17, 83-124, (1978)

Loading...


Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Tummala KS, Gomes AL, Yilmaz M, et al. Cancer Cell 26(6), 826-39, (2014)

Loading...


Bridelia ferruginea promotes reactive oxygen species detoxification in N-nitrosodiethylamine-treated rats. Ajiboye TO, Abdussalam FA, Adeleye AO, et al. J. Diet. Suppl. 10(3), 210-28, (2013)

Loading...


Diethylnitrosamine-induced redox imbalance in rat microsomes: protective role of polyphenolic-rich extract from Sorghum bicolor grains. Ajiboye TO, Komolafe YO, Bukoye Oloyede HO, et al. J. Basic Clin. Physiol. Pharmacol. 24(1), 41-9, (2013)

Loading...


The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

Loading...


N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Verna L, Whysner J, and Williams GM Pharmacol. Ther. 71(1-2), 57-81, (1996)

Loading...


Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents. Walesky C, Edwards G, Borude P, et al. Hepatology 57(6), 2480-90, (2013)

Loading...


Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Fuchs BC, Hoshida Y, Fujii T, et al. Hepatology 59(4), 1577-90, (2014)

Loading...


Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis. Suresh V, Anbazhagan C, Thangam R, et al. Carbohydr. Polym. 92(2), 1377-85, (2013)

Loading...


Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice. Wang Z, Yan J, Lin H, et al. Hepatology 57(5), 1869-81, (2013)

Loading...


Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB. Rehman MU, Tahir M, Khan AQ, et al. Toxicol. Lett. 216(2-3), 146-58, (2013)

Loading...


Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats. Fujii Y, Kimura M, Ishii Y, et al. Toxicology 305, 30-40, (2013)

Loading...


Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine. Miyakoshi M, Yamamoto M, Tanaka H, et al. Mol. Carcinog. 53(1), 67-76, (2014)

Loading...


Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. Xu B, Li SH, Zheng R, et al. Proc. Natl. Acad. Sci. U. S. A. 110(43), 17480-5, (2013)

Loading...


Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. Chappell G, Kutanzi K, Uehara T, et al. Int. J. Cancer 134(12), 2778-88, (2014)

Loading...


Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis. Gupta P, Bansal MP, and Koul A Biochem. Biophys. Res. Commun. 434(3), 479-85, (2013)

Loading...


Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer. Jin J, Iakova P, Jiang Y, et al. J. Biol. Chem. 288(20), 14451-62, (2013)

Loading...


Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Uehara T, Ainslie GR, Kutanzi K, et al. Toxicol. Sci. 132(1), 53-63, (2013)

Loading...


Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats. Sun K, Guo XL, Zhao QD, et al. Cell Death Dis. 4, e501, (2013)

Loading...


Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. Saraswati S, Alhaider AA, and Agrawal SS Chem. Biol. Interact. 206(2), 214-21, (2013)

Loading...


Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Guariento AH, Furtado KS, de Conti A, et al. Int. J. Cancer 135(1), 7-18, (2014)

Loading...


Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine. Yuan F, Lu J, You P, et al. Proteomics 13(2), 389-97, (2013)

Loading...


Influence of various cooking methods on the concentrations of volatile N-nitrosamines and biogenic amines in dry-cured sausages. Li L, Wang P, Xu X, et al. J. Food Sci. 77(5), C560-5, (2012)

Loading...


Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Arul D and Subramanian P Biochem. Biophys. Res. Commun. 434(2), 203-9, (2013)

Loading...


Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Shaban NZ, El-Kersh MA, El-Rashidy FH, et al. Food Chem. 141(3), 1587-96, (2013)

Loading...


Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system. Gupta P, Bansal MP, and Koul A Chem. Biol. Interact. 206(2), 364-74, (2013)

Loading...


Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation. Zhong Q, Shi G, Zhang Q, et al. Carcinogenesis 34(11), 2460-9, (2013)

Loading...


Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Chowdhury G, Calcutt MW, Nagy LD, et al. Biochemistry 51(50), 9995-10007, (2012)

Loading...


Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice. Hu WT, Li HC, Lee SK, et al. Biochem. Biophys. Res. Commun. 435(1), 147-52, (2013)

Loading...


Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. Bingül İ, Başaran-Küçükgergin C, Tekkeşin MS, et al. Environ. Toxicol. Pharmacol. 36(2), 529-38, (2013)

Loading...


The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model. Macías-Pérez JR, Beltrán-Ramírez O, Vásquez-Garzón VR, et al. Anticancer Drugs 24(4), 394-405, (2013)

Loading...


High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice. Ip BC, Liu C, Smith DE, et al. J. Nutr. 144(5), 647-53, (2014)

Loading...


Androgen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cells. Ma WL, Jeng LB, Lai HC, et al. Cancer Lett. 351(1), 64-71, (2014)

Loading...


Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. Wei M, Yamada T, Yamano S, et al. Toxicol. Appl. Pharmacol. 273(1), 1-9, (2013)

Loading...


Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma. Sengupta D, Chowdhury KD, Sarkar A, et al. Biochim. Biophys. Acta 1840(1), 219-44, (2014)

Loading...


Possible role of selective, irreversible, proteasome inhibitor (carfilzomib) in the treatment of rat hepatocellular carcinoma. Mansour MA, Aljoufi MA, Al-Hosaini K, et al. Chem. Biol. Interact. 215, 17-24, (2014)

Loading...


Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice. Nagappan A, Park HS, Park KI, et al. Chem. Biol. Interact. 206(2), 143-52, (2013)

Loading...


Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats. Fujii Y, Segawa R, Kimura M, et al. Chem. Biol. Interact. 205(2), 108-18, (2013)

Loading...


Comparative proteomic analysis of thiol proteins in the liver after oxidative stress induced by diethylnitrosamine. Aparicio-Bautista DI, Pérez-Carreón JI, Gutiérrez-Nájera N, et al. Biochim. Biophys. Acta 1834(12), 2528-38, (2013)

Loading...


Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats. Atakisi O, Atakisi E, Ozcan A, et al. Eur. Rev. Med. Pharmacol. Sci. 17(4), 467-71, (2013)

Loading...


Bone marrow-derived cells contribute to NDEA-induced lung squamous cell carcinoma. Luo D, Liu D, Zhou X, et al. Tumour Biol. 34(1), 145-54, (2013)

Loading...


Histology, bioenergetics and oxidative stress in mouse liver exposed to N-diethylnitrosamine. Santos NP, Pereira IC, Pires MJ, et al. In Vivo 26(6), 921-9, (2012)

Loading...


Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats. Yamamoto R, Shimamoto K, Ishii Y, et al. Exp. Toxicol. Pathol. 65(6), 845-52, (2013)

Loading...


Elevated expression of complement C3 protein in chemically induced hepatotumorogenesis in Wistar rats: a correlative proteomics and histopathological study. Malik S, Bhatnagar S, Chaudhary N, et al. Exp. Toxicol. Pathol. 65(6), 767-73, (2013)

Loading...


Synergistic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine on cell malignant transformation. Zhang L, Zhao R, Ye SQ, et al. Biomed. Environ. Sci. 26(5), 323-30, (2013)

Loading...


Inductive effect of phytoglycoprotein (38 kDa) on G₀/G₁ arrest and apoptosis in diethylnitrosamine-treated ICR mice. Lee J and Lim KT Mol. Cell Biochem. 375(1-2), 31-8, (2013)

Loading...


Hepatocyte growth factor promotes lung carcinogenesis in transgenic mice treated with diethylnitrosamine. Kojima A, Horiguchi N, Kakizaki S, et al. Anticancer Res. 33(3), 895-901, (2013)

Loading...


Increased expression of epithelial cell adhesion molecule (EpCAM) in rat hepatic tumors induced by diethylnitrosamine. Kang JS Asian Pac. J. Cancer Prev. 13(8), 3627-30, (2012)

Loading...


Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin. Cardinale V, Carpino G, Reid LM, et al. Hepatology 58(3), 1188, (2013)

Loading...


Merck 14,6636

Beil. 4,IV,3386

Related Products

ISOPAC of

Product #

Description

Add to Cart

N0756 N-Nitrosodiethylamine, liquid

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?