Anti-Nicastrin antibody produced in rabbit

References

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Nicalin and its binding partner Nomo are novel Nodal signaling antagonists Haass, C., et al. EMBO J. 23, 3041-3050, (2004)

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CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer’s disease amyloid β-peptide production. Jap, B.K., et al. Proc. Natl. Acad. Sci. U. S. A. 102, 7499-7504, (2005)

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Aph-1 Associates Directly With Full-length And C-terminal Fragments Of Gamma-Secretase Substrates Chen, A., et al. J. Biol. Chem. 285, 11378 - 11391, (2010)

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Human CRB2 Inhibits Gamma-Secretase Cleavage Of Amyloid Precursor Protein By Binding To The Presenilin Complex Mitsuishi, Y., et al. J. Biol. Chem. 285, 14920 - 14931, (2010)

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Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. Watanabe, N., et al. J. Biol. Chem. 285, 19738-46, (2010)

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The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. Ullrich, S., et al. J. Biol. Chem. 285, 20664-74, (2010)

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The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing. Wanngren, J., et al. J. Biol. Chem. 285, 8527-36, (2010)

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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. Berger, Z., et al. Biochemistry 49, 5511-23, (2010)

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CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2. Nahalkova, J., et al. Neurochem. Int. 56, 67-76, (2010)

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Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization. Fassler, M., et al. J. Biol. Chem. 286, 38390-6, (2011)

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Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. Ohki, Y., et al. EMBO J. 30, 4815-24, (2011)

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Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates. Barthet, G., et al. FASEB J. 25, 2937-46, (2011)

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Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain. FrÃ¥nberg, J., et al. Biochem. Biophys. Res. Commun. 404, 564-8, (2011)

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γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio. Hedskog, L., et al. J. Cell. Mol. Med. 15, 2150-63, (2011)

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