|Related Categories||Biochemicals and Reagents, NAD(P)(H) Analogs, NAD(P)(H) and Analogs, Nucleosides, Nucleotides, Oligonucleotides|
|mp||291-293 °C (dec.)(lit.)|
Nicotinamide N-oxide is a niacin-related compound used in studies of mechanisms of niacin-related granulocyte differentiation of cells such as human promyelocytic leukemia cells (HL-60). Nicotinamide N-oxide reduced expression of c-myc in HL-60 cell line.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N3258.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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|Precautionary statements||P261-P305 + P351 + P338|
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|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
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Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds. Ida C, Ogata S, Okumura K, Taguchi H. Biosci. Biotechnol. Biochem. 72, 868-871, (2008)
Spectroscopic (NMR, UV, FT-IR and FT-Raman) analysis and theoretical investigation of nicotinamide N-oxide with density functional theory. Atac A, Karabacak M, Kose E, Karaca C. Spectrochim. Acta A 83(1), 250-258, (2011)
Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer. Bernier J, Stratford MR, Denekamp J, et al. Radiother. Oncol. 48(2), 123-33, (1998)
NAD (P) H-dependent reduction of nicotinamide N-oxide by an unique enzyme system consisting of liver microsomal NADPH-cytochrome C reductase and cytosolic aldehyde oxidase. Kitamura S, Wada Y, and Tatsumi K Biochem. Biophys. Res. Commun. 125(3), 1117-22, (1984)
Spectroscopic (NMR, UV, FT-IR and FT-Raman) analysis and theoretical investigation of nicotinamide N-oxide with density functional theory. Atac A, Karabacak M, Kose E, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1), 250-8, (2011)
Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation. Menon RM, Adams MH, González MA, et al. Int. J. Clin. Pharmacol. Ther. 45(8), 448-54, (2007)
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats. Fukuwatari T, Wada H, Sasaki R, et al. Biosci. Biotechnol. Biochem. 68(1), 44-50, (2004)
Aldrich MSDS 1, 1348:D / Corp MSDS 1 (2), 2540:D / FT-IR 1 (2), 917:A / FT-IR 2 (3), 3998:A / IR-Spectra (2), 1240:A / IR-Spectra (3), 1423:A / NMR-Reference 2 (2), 777:D / RegBook 1 (2), 2681:M / Sigma FT-IR 1 (2), 772:D / Structure Index 1, 421:E:7
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