Nisin from Lactococcus lactis
2.5% (balance sodium chloride and denatured milk solids)
DOWNLOAD MSDS (PDF)-
CAS Number 1414-45-5
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Empirical Formula (Hill Notation) C143H230N42O37S7
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Molecular Weight 3354.07
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MDL number MFCD00131724
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PubChem Substance ID 24897751
Properties
| Related Categories | Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, |
| potency | ≥1,000,000 per IU/g |
| concentration | 2.5% (balance sodium chloride and denatured milk solids) |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots.
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).
Nisin binds to cell wall precursor lipid components (lipid A portion) of bacteria and disrupts cell wall production. Nisin alters the cell membrane which results in the leakage of cytoplasmic components and destruction of the proton motive force1.
Packaging
Package size based on weight of total solids
Application
Nisin is a polycyclic lantibiotic produced by Lactococcus lactis. It is commonly used as a food preservative. It is used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and moulds. Product N54764 has been used in bioassays to study posttranslational modification of nisin1. Nisin is used to study food preservation.
Price and Availability
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