|Related Categories||Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,|
|potency||≥1,000,000 per IU/g|
|concentration||2.5% (balance sodium chloride and denatured milk solids)|
Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots.
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).
Nisin binds to cell wall precursor lipid components (lipid A portion) of bacteria and disrupts cell wall production. Nisin alters the cell membrane which results in the leakage of cytoplasmic components and destruction of the proton motive force1.
Package size based on weight of total solids
Nisin is a polycyclic lantibiotic produced by Lactococcus lactis. It is commonly used as a food preservative. It is used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and moulds. Product N54764 has been used in bioassays to study posttranslational modification of nisin1. Nisin is used to study food preservation.
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Keywords: Antibiotics, Antimicrobials, Antiparasitics, Antivirals, Apoptosis, Cancer, Clinical, Diseases, Environmental, Fermentation, Food Safety, Gene expression, Genetic, Genetics, Infectious Diseases, Microbiology, Peptide synthesis, Pesticides, Respiratory
Nisin, rosemary, and ethylenediaminetetraacetic acid affect the growth of Listeria monocytogenes on ready-to-eat turkey ham stored at four degrees Celsius for sixty-three days A. Ruiz, S. K. Williams, et al . Poult. Sci. 88, 1765-1772, (2009)
Effect of combining nisin with modified atmosphere packaging on inhibition of Listeria monocytogenes in ready-to-eat turkey bologna. Naas H, Martinez-Dawson R, Han I, et al. Poult. Sci. 92(7), 1930-5, (2013)
In situ determination of Clostridium endospore membrane fluidity during pressure-assisted thermal processing in combination with nisin or reutericyclin. Hofstetter S, Winter R, McMullen LM, et al. Appl. Environ. Microbiol. 79(6), 2103-6, (2013)
[Characteristics and identification of bacteriocins produced by Lactococcus lactis subsp. lactis 194-K]. Ustiugova EA, Timofeeva AV, Stoianova LG, et al. Prikl. Biokhim. Mikrobiol. 48(6), 618-25, (2012)
Antimicrobial packaging to retard the growth of spoilage bacteria and to reduce the release of volatile metabolites in meat stored under vacuum at 1°C. Ferrocino I, La Storia A, Torrieri E, et al. J. Food Prot. 76(1), 52-8, (2013)
Isolation and characterization of a nisin-like bacteriocin produced by a Lactococcus lactis strain isolated from charqui, a Brazilian fermented, salted and dried meat product. Biscola V, Todorov SD, Capuano VS, et al. Meat Science 93(3), 607-13, (2013)
Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis by Streptococcus mutans. Yamakami K, Tsumori H, Sakurai Y, et al. Pharm. Biol. 51(2), 267-70, (2013)
In vitro activities of antibiotics and antimicrobial cationic peptides alone and in combination against methicillin-resistant Staphylococcus aureus biofilms. Mataraci E and Dosler S Antimicrob. Agents Chemother. 56(12), 6366-71, (2012)
Influence of alanine uptake on Staphylococcus aureus surface charge and its susceptibility to two cationic antibacterial agents, nisin and low molecular weight chitosan. Chen LC, Chiang WD, Chen WC, et al. Food Chem. 135(4), 2397-403, (2012)
Effects of nisin and lysozyme on growth inhibition and biofilm formation capacity of Staphylococcus aureus strains isolated from raw milk and cheese samples. Sudagidan M and Yemenicioğlu A J. Food Prot. 75(9), 1627-33, (2012)
Effects of temperature and trehalose on foam separation of nisin from the culture broth produced by Lactococcus lactis subspecies lactis W28. Wang Y, Nan F, Zheng H, et al. J. Dairy Sci. 95(10), 5588-96, (2012)
Chemical composition and antioxidative activity of Echinophora platyloba DC. essential oil, and its interaction with natural antimicrobials against food-borne pathogens and spoilage organisms. Saei-Dehkordi SS, Fallah AA, Saei-Dehkordi SS, et al. J. Food Sci. 77(11), M631-7, (2012)
Response of Bacillus cereus vegetative cells after exposure to repetitive sublethal radiation processing in combination with nisin. Ayari S, Dussault D, Hayouni el A, et al. Food Microbiol. 32(2), 361-70, (2012)
Proteomic response of Bacillus subtilis to lantibiotics reflects differences in interaction with the cytoplasmic membrane. Wenzel M, Kohl B, Münch D, et al. Antimicrob. Agents Chemother. 56(11), 5749-57, (2012)
Lerner, H.R., et al. Physiol. Plant. 57, 90, (1983)
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