|Related Categories||Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Proteins More...|
|recombinant||expressed in E. coli|
|mol wt||apparent mol wt ~27 kDa|
|mol wt ~31 kDa|
|shipped in||dry ice|
|Gene Information||human ... PPP1R1A(5502), PPP1R8(5511)|
This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies.
Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.1
Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol
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aqueous solution (dark coloration may develop upon storage, which does not affect the activity)
for use with mammalian cell and tissue extracts, DMSO solution
recombinant, expressed in E. coli, buffered aqueous glycerol solution
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