|Related Categories||Agonists, Alkaloids, Analytical Standards, Analytical/Chromatography, Approved Therapeutics/Drug Candidates,|
|solubility||H2O: soluble100 mg/mL|
|Gene Information||human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)|
Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
Hygroscopic, light sensitive
Shelf life of the powder is at least five years.
5, 10, 50 g in poly bottle
Certificate of Analysis
Certificate of Origin
Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled receptors (GPCRs). They are relatively abundant and mediate many of the diverse actions of acetylcholine in the ...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Gene expression, Hormones, Molecular biology, Neurotransmitters, Parkinson Disease, Polymorphisms, Transduction
Up-regulation Of D-serine Might Induce GABAergic Neuronal Degeneration In The Cerebral Cortex And Hippocampus In The Mouse Pilocarpine Model Of Epilepsy. Liu, Y.H., et al. Neurochem. Res. 34, 1209-18, (2009)
Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants. Strupińska M, Rostafińska-Suchar G, Pirianowicz-Chaber E, et al. Acta Pol. Pharm. 70(4), 681-6, (2013)
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. Faure JB, Akimana G, Carneiro JE, et al. Epilepsia 54(7), 1203-13, (2013)
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. Smeland OB, Hadera MG, McDonald TS, et al. J. Cereb. Blood Flow Metab. 33(7), 1090-7, (2013)
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Jiang J, Quan Y, Ganesh T, et al. Proc. Natl. Acad. Sci. U. S. A. 110(9), 3591-6, (2013)
Low-intensity physical training recovers object recognition memory impairment in rats after early-life induced Status epilepticus. Córdova SD, Loss CM, and de Oliveira DL Int. J. Dev. Neurosci. 31(3), 196-201, (2013)
Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. Jou SB, Kao IF, Yi PL, et al. Seizure 22(3), 221-9, (2013)
Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus. Risbud RM and Porter BE PLoS ONE 8(1), e53464, (2013)
Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus. Oh YJ, Na J, Jeong JH, et al. BMB Rep. 45(11), 635-40, (2012)
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Phelan KD, Shwe UT, Abramowitz J, et al. Mol. Pharmacol. 83(2), 429-38, (2013)
In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models. Pulido-Rios MT, McNamara A, Obedencio GP, et al. J. Pharmacol. Exp. Ther. 346(2), 241-50, (2013)
Effect of selective stimulation of muscarinic M3 cholinoceptors on electrical and contractile activity of rat ventricular myocardium. Abramochkin DV, Tapilina SV, and Sukhova GS Bull. Exp. Biol. Med. 154(3), 295-8, (2013)
The antiepileptic effect of the glycolytic inhibitor 2-deoxy-D-glucose is mediated by upregulation of K(ATP) channel subunits Kir6.1 and Kir6.2. Yang H, Guo R, Wu J, et al. Neurochem. Res. 38(4), 677-85, (2013)
Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: the resultant damage is similar to very old brains. Karbowski LM, Parker GH, and Persinger MA Epilepsy Behav. 27(1), 18-21, (2013)
Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. Yu J, Proddutur A, Elgammal FS, et al. J. Neurophysiol. 109(7), 1746-63, (2013)
Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat. Dube, C., et al. Exp. Neurol. 162, 146-157, (2000)
Aldrich MSDS 1, 1495:B / Corp MSDS 1 (2), 2838:A / FT-IR 2 (3), 3524:A / FT-IR 1 (2), 624:C / FT-NMR 1 (3), 86:C / IR-Spectra (3), 1224:C / IR-Spectra (2), 1065:E / NMR-Reference 2 (2), 496:B / RegBook 1 (2), 2365:B / Sax 6, 2232 / Sigma FT-IR 1 (1), 598:A / Structure Index 1, 375:D:1
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