P9564 Sigma

Phleomycin from Streptomyces verticillus

powder

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Description

Biochem/physiol Actions

Phleomycin is a structurally related form of the antibiotic, bleomycin. Phleomycin blocks S-phase entry in the cell cycle. While phleomycin can damage DNA, like bleomycin, it is not used as an anticancer agent, but rather as a selection agent. The RAD6 DNA repair gene is essential for phleomycin resistance in mutant yeast.

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