Synonym: Benzylpenicillin sodium salt
|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Apoptosis and Cell Cycle, Biochemicals and Reagents,|
Mode of Action: Inhibits bacterial cell wall synthesis.
Antimicrobial spectrum: Gram-positive bacteria.
Penicillin G is active against gram-positive and gram-negative aerobic and anaerobic bacteria. Penicillin G inhibits cell wall synthesis by binding to penicillin binding proteins (PBPs), which inhibits peptidoglycan chain cross-linking. Penicillin G is stable against hydrolysis by β-lactamases, such as penicillinases and cephalosporinases.
Penicillin G is narrow spectrum antibiotic. It is the drug of choice for Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G sodium salt is used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility 1. It is used in cell culture alone as well as in combination with streptomcyin and other antibiotics2.
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powder, BioReagent, suitable for cell culture
powder, BioReagent, suitable for cell culture
Solution stabilized, with 10,000 units penicillin and 10 mg streptomycin/mL, sterile-filtered, BioReagent, suitable for cell culture
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P342 + P311|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||42/43|
|Safety Statements (Europe)||22-36/37-45|
Antibiotics are molecules that specifically target and kill cells. The term antibiotic is frequently used interchangeably with the word antibacterial, but antiviral, antifungal and antineoplastic com...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antifungals, Antivirals, Building blocks, Glycosylations, Metabolism
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan. Hotomi M, Togawa A, Kono M, et al. PLoS ONE 8(3), e58124, (2013)
Synthesis, characterization of penicillin G capped silver nanoconjugates to combat β-lactamase resistance in infectious microorganism. Ahmed V, Kumar J, Kumar M, et al. J. Biotechnol. 163(4), 419-24, (2013)
Chromogenic substrate from 4-nitro-1-naphthol for hydrolytic enzyme of neutral or slightly acidic optimum pH: 4-nitro-1-naphthyl-β-D-galactopyranoside as an example. Dang J, Liu H, Yang X, et al. Bioorg. Med. Chem. Lett. 23(3), 646-9, (2013)
R164H and V240H replacements by site-directed mutagenesis of TEM-149 extended-spectrum β-lactamase: kinetic analysis of TEM-149H240 and TEM-149H164-H240 laboratory mutants. Perilli M, Celenza G, Mercuri PS, et al. Antimicrob. Agents Chemother. 57(2), 1047-9, (2013)
Comparing a combination of penicillin G and gentamicin to a combination of clindamycin and amikacin as prophylactic antibiotic regimens in prevention of clean contaminated wound infections in cancer surgery. El-Mahallawy HA, Hassan SS, Khalifa HI, et al. J. Egypt. Natl. Canc. Inst. 25(1), 31-5, (2013)
Streptococcus gallolyticus subspecies pasteurianus meningitis in an infant: a case report and literature review. Punpanich W, Munsrichoom A, and Dejsirilert S J. Med. Assoc. Thai. 95(12), 1606-12, (2012)
Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. Komazawa H, Yamaguchi H, Hidaka K, et al. J. Pharm. Sci. 102(3), 1086-94, (2013)
The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator. Martín J, García-Estrada C, Kosalková K, et al. Fungal Genet. Biol. 49(12), 1004-13, (2012)
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)
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