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PZ0171 Sigma

CP-100356 monohydrochloride

>98% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

  • CAS Number 142715-48-8

  • Empirical Formula (Hill Notation) C31H36N4O6 · HCl

  • Molecular Weight 597.10

  •  MDL number MFCD00911858

CP-100356 monohydrochloride >98% (HPLC)
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Properties

Related Categories Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Modulators for MDR/TAP Transporters,
assay   >98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >5 mg/mL
storage temp.   2-8°C

Description

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).

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