Avasimibe
≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
CI-1011; PD 148515; [[2,4,6-
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CAS Number 166518-60-1
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Empirical Formula (Hill Notation) C29H43NO4S
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Molecular Weight 501.72
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MDL number MFCD00934956
Properties
| Related Categories | AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥40 mg/mL |
| storage temp. | room temp |
Description
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).
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