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R1276 - Reversin 121

R1276 Sigma

Reversin 121

≥97% (HPLC), powder

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Synonym: Boc-Asp(Obzl)-Lys(Z)-OtBu

Empirical Formula (Hill Notation) C₃₄H₄₇N₃O₉
Molecular Weight 641.75
MDL number MFCD03788012
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Properties

Related Categories	Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Membrane Protein Biology Tools, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, P to Q, P-Glycoprotein, Proteins and Derivatives, R More...
assay	≥97% (HPLC)
form	powder
color	white
solubility	DMSO or ethanol: soluble
storage temp.	−20°C
Gene Information	human ... GRIN2A(2903) mouse ... GRIN2A(14811) rat ... GRIN2A(24409)

Description

Biochem/physiol Actions

Peptide chemosensitizer, inhibitor of P-glycoprotein.

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Related Papers

Interaction of the p-Glycoprotein Multidrug Transporter (MDR1) with High Affinity Peptide Chemosensitizers in Isolated Membranes, Reconstituted Systems, and Intact Cells. Sharom, F.J., et al. Biochem. Pharmacol. 58, 571, (1999)

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Articles

Drug Transport

Protein-based drug transporters are found in most tissues including liver, kidney, intestine, and brain. Because of their complexity and genetic heterogeneity, these proteins are often produced as re...
Robert Gates
Biofiles Volume 6 Article 1
Keywords: Absorption, Anti-inflammatory agents, Antibiotics, Antimicrobials, Apoptosis, Cancer, Cytotoxins, Detoxification, Enzyme-linked immunosorbent assay, Gene expression, Genetic, High performance liquid chromatography, Immunohistochemistry, Mass spectrometry, Metabolites, Phosphorylations, Separation, Transfection, Western blot

The Cancer Stem Cell Hypothesis

Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
Vicki Caligur
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation

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