Rifampicin

Papers

1. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, et al. Nucleic Acids Res. 39, D1035-41., (2011)

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2. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis M I Prince, A D Burt, et al. Gut 50, 436-439, (2002)

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Swarming and complex pattern formation in Paenibacillus vortex studied by imaging and tracking cells. Colin J Ingham et al BMC Microbiol. 8, 36, (2008)

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Modifying Culture Conditions In Chemical Library Screening Identifies Alternative Inhibitors Of Mycobacteria. Miller, C.H., et al. Antimicrob. Agents Chemother. 53, 5279-83, (2009)

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Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines. N. Duewelhenke, O. Krut, et al. Antimicrob. Agents Chemother. 51, 54-63, (2007)

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Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents. Andrés Jaso et al J. Med. Chem. 48, 2019-25, (2005)

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Design and studies of novel 5-substituted alkynylpyrimidine nucleosides as potent inhibitors of mycobacteria. Dinesh Rai et al J. Med. Chem. 48, 7012-7, (2005)

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Koen Andries et al Science 307, 223-7, (2005)

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Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents. Neelima Sinha et al Bioorg. Med. Chem. Lett. 15, 1573-6, (2005)

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Identification of heteroarylenamines as a new class of antituberculosis lead molecules. Brent R Copp et al Bioorg. Med. Chem. Lett. 15, 4097-9, (2005)

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Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes. Gautam Panda et al Bioorg. Med. Chem. Lett. 15, 5222-5, (2005)

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Antitubercular constituents from the stem wood of Cinnamomum kotoense. Fu-Chi Chen et al J. Nat. Prod. 68, 1318-23, (2005)

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Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. Kithsiri B Herath et al J. Nat. Prod. 68, 1437-40, (2005)

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Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua. Anthony D Wright et al J. Nat. Prod. 68, 459-61, (2005)

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Discovery of new antitubercular oxazolyl thiosemicarbazones. Dharmarajan Sriram et al J. Med. Chem. 49, 3448-50, (2006)

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Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity. Mariangela Biava et al J. Med. Chem. 49, 4946-52, (2006)

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Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles. Hirofumi Sasaki et al J. Med. Chem. 49, 7854-60, (2006)

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Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 16, 1164-7, (2006)

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Search of antitubercular activities in tetrahydroacridines: synthesis and biological evaluation. R P Tripathi et al Bioorg. Med. Chem. Lett. 16, 5144-7, (2006)

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New rifabutin analogs: synthesis and biological activity against Mycobacterium tuberculosis. José Barluenga et al Bioorg. Med. Chem. Lett. 16, 5717-22, (2006)

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Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. Karumanchi V Rao et al J. Nat. Prod. 69, 1034-40, (2006)

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Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima. Wantana Mongkolvisut et al J. Nat. Prod. 69, 1435-41, (2006)

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(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. Anders Vik et al J. Nat. Prod. 69, 381-6, (2006)

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Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. Jin-Feng Hu et al J. Nat. Prod. 69, 585-90, (2006)

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Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera. Rosario Rojas et al J. Nat. Prod. 69, 845-6, (2006)

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OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. Makoto Matsumoto et al PLoS Med. 3, e466, (2006)

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Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Sadanandan E Velu et al J. Med. Chem. 50, 2612-21, (2007)

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Growth inhibition of Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium in vitro: effect of 1-beta-D-2'-arabinofuranosyl and 1-(2'-deoxy-2'-fluoro-beta-D-2'-ribofuranosyl) pyrimidine nucleoside analogs. Monika Johar et al J. Med. Chem. 50, 3696-705, (2007)

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Discovery of 1,4-dihydroxy-2-naphthoate [corrected] prenyltransferase inhibitors: new drug leads for multidrug-resistant gram-positive pathogens. Michio Kurosu et al J. Med. Chem. 50, 3973-5, (2007)

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Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. Philippe Villain-Guillot et al J. Med. Chem. 50, 4195-204, (2007)

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Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. Abbas Gholipour Shilabin et al J. Med. Chem. 50, 4340-50, (2007)

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Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides. Dinesh Rai et al J. Med. Chem. 50, 4766-74, (2007)

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New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents. Lluis Ballell et al Bioorg. Med. Chem. Lett. 17, 1736-40, (2007)

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N-Hydroxythiosemicarbazones: synthesis and in vitro antitubercular activity. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 17, 1888-91, (2007)

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Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus. Taku Chiba et al Bioorg. Med. Chem. Lett. 17, 2487-91, (2007)

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Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines. Kapil Arya et al Bioorg. Med. Chem. Lett. 17, 3298-304, (2007)

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[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains. Antonio Carta et al Bioorg. Med. Chem. Lett. 17, 4791-4, (2007)

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New C25 carbamate rifamycin derivatives are resistant to inactivation by ADP-ribosyl transferases. Keith D Combrink et al Bioorg. Med. Chem. Lett. 17, 522-6, (2007)

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Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 17, 5419-22, (2007)

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Preparation and in vitro anti-staphylococcal activity of novel 11-deoxy-11-hydroxyiminorifamycins. Jing Li et al Bioorg. Med. Chem. Lett. 17, 5510-3, (2007)

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Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives. Sajal Kumar Das et al Bioorg. Med. Chem. Lett. 17, 5586-9, (2007)

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Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives. Mauro V de Almeida et al Bioorg. Med. Chem. Lett. 17, 5661-4, (2007)

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Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents. Maria Cristina Silva Lourenço et al Bioorg. Med. Chem. Lett. 17, 6895-8, (2007)

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Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents. Tugba Ertan et al Bioorg. Med. Chem. 15, 2032-44, (2007)

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Studies on acyclic pyrimidines as inhibitors of mycobacteria. Naveen C Srivastav et al Bioorg. Med. Chem. 15, 2045-53, (2007)

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N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus. Kevin D Revell et al Bioorg. Med. Chem. 15, 2453-67, (2007)

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Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents. Mahendra Ramesh Shiradkar et al Bioorg. Med. Chem. 15, 3997-4008, (2007)

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Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. Anders Vik et al Bioorg. Med. Chem. 15, 4016-37, (2007)

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Synthesis and antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines. Gabriel Navarrete-Vázquez et al Bioorg. Med. Chem. 15, 5502-8, (2007)

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Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives. Nilgün Karali et al Bioorg. Med. Chem. 15, 5888-904, (2007)

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Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method. Daniele Zampieri et al Bioorg. Med. Chem. 15, 7444-58, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives. Aline F Taveira et al Bioorg. Med. Chem. 15, 7789-94, (2007)

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Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents. Mauro Vieira de Almeida et al Eur. J. Med. Chem. 42, 1076-83, (2007)

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Clubbed triazoles: a novel approach to antitubercular drugs. Mahendra Shiradkar et al Eur. J. Med. Chem. 42, 807-16, (2007)

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Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosis. M Ibrahim et al Antimicrob. Agents Chemother. 51, 1011-5, (2007)

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Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Juyan Zhou et al Antimicrob. Agents Chemother. 51, 1085-8, (2007)

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Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. Radosław Izdebski et al Antimicrob. Agents Chemother. 51, 1155-63, (2007)

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Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. Hervé Nicoloff et al Antimicrob. Agents Chemother. 51, 1293-303, (2007)

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Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Sang Hyun Cho et al Antimicrob. Agents Chemother. 51, 1380-5, (2007)

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Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology. Kim Credito et al Antimicrob. Agents Chemother. 51, 1504-7, (2007)

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Metronidazole plus rifampin sterilizes long-term dormant Mycobacterium tuberculosis. Elisabetta Iona et al Antimicrob. Agents Chemother. 51, 1537-40, (2007)

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Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus. Aldona L Baltch et al Antimicrob. Agents Chemother. 51, 1559-62, (2007)

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Horizontal Gene Transfer of ftsI, Encoding Penicillin-Binding Protein 3, in Haemophilus influenzae. Sho Takahata, Takashi Ida, et. Al Antimicrob. Agents Chemother. 51, 1589 - 1595, (2007)

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In vitro activities of various antimicrobials alone and in combination with tigecycline against carbapenem-intermediate or -resistant Acinetobacter baumannii. Marc H Scheetz et al Antimicrob. Agents Chemother. 51, 1621-6, (2007)

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Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Issam Raad et al Antimicrob. Agents Chemother. 51, 1656-60, (2007)

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Isoniazid induces its own resistance in nonreplicating Mycobacterium tuberculosis. Salman Siddiqi et al Antimicrob. Agents Chemother. 51, 2100-4, (2007)

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High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilm. Linda M Weigel et al Antimicrob. Agents Chemother. 51, 231-8, (2007)

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Efficacy of a novel rifamycin derivative, ABI-0043, against Staphylococcus aureus in an experimental model of foreign-body infection. Andrej Trampuz et al Antimicrob. Agents Chemother. 51, 2540-5, (2007)

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Pharmacokinetics and tolerability of a higher rifampin dose versus the standard dose in pulmonary tuberculosis patients. Rovina Ruslami et al Antimicrob. Agents Chemother. 51, 2546-51, (2007)

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Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. Alex Soriano et al Antimicrob. Agents Chemother. 51, 2559-63, (2007)

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Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Michael Meehl et al Antimicrob. Agents Chemother. 51, 2679-89, (2007)

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Effects of rifampin and multidrug resistance gene polymorphism on concentrations of moxifloxacin. Marc Weiner et al Antimicrob. Agents Chemother. 51, 2861-6, (2007)

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Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. A H Diacon et al Antimicrob. Agents Chemother. 51, 2994-6, (2007)

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Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum. T N C Ramya et al Antimicrob. Agents Chemother. 51, 307-16, (2007)

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Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Edward P Acosta et al Antimicrob. Agents Chemother. 51, 3104-10, (2007)

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In vitro activities of different inhibitors of bacterial transcription against Staphylococcus epidermidis biofilm. Philippe Villain-Guillot et al Antimicrob. Agents Chemother. 51, 3117-21, (2007)

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Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Astrid Pérez et al Antimicrob. Agents Chemother. 51, 3247-53, (2007)

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Induction of voriconazole metabolism by rifampin in a patient with acute myeloid leukemia: importance of interdisciplinary communication to prevent treatment errors with complex medications. Marcus J P Geist et al Antimicrob. Agents Chemother. 51, 3455-6, (2007)

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Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Erica L Dahl et al Antimicrob. Agents Chemother. 51, 3485-90, (2007)

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Orally administered combined regimens for treatment of Mycobacterium ulcerans infection in mice. Baohong Ji et al Antimicrob. Agents Chemother. 51, 3737-9, (2007)

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Concentration-dependent Mycobacterium tuberculosis killing and prevention of resistance by rifampin. Tawanda Gumbo et al Antimicrob. Agents Chemother. 51, 3781-8, (2007)

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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Andrew E Simor et al Antimicrob. Agents Chemother. 51, 3880-6, (2007)

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Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Hui Wang et al Antimicrob. Agents Chemother. 51, 4022-8, (2007)

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Rifampin inhibits prostaglandin E2 production and arachidonic acid release in human alveolar epithelial cells. Yael Yuhas et al Antimicrob. Agents Chemother. 51, 4225-30, (2007)

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Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. John D Szumowski et al Antimicrob. Agents Chemother. 51, 423-8, (2007)

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Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Sean T Byrne et al Antimicrob. Agents Chemother. 51, 4495-7, (2007)

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Antimicrobial susceptibilities and clinical sources of Dialister species. F Morio et al Antimicrob. Agents Chemother. 51, 4498-501, (2007)

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Curing Mycobacterium ulcerans infection in mice with a combination of rifampin-streptomycin or rifampin-amikacin. Sébastien Lefrançois et al Antimicrob. Agents Chemother. 51, 645-50, (2007)

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Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Trudy H Grossman et al Antimicrob. Agents Chemother. 51, 657-66, (2007)

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Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Ze-Qing Wei et al Antimicrob. Agents Chemother. 51, 763-5, (2007)

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Caenorhabditis elegans as a model to determine fitness of antibiotic-resistant Salmonella enterica serovar typhimurium. Wilhelm Paulander et al Antimicrob. Agents Chemother. 51, 766-9, (2007)

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In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. Kristi L Frank et al Antimicrob. Agents Chemother. 51, 888-95, (2007)

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Diarylquinolines target subunit c of mycobacterial ATP synthase. Anil Koul et al Nat. Chem. Biol. 3, 323-4, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings. Mariangela Biava et al J. Med. Chem. 51, 3644-8, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. Christopher Fotsch et al J. Med. Chem. 51, 7953-67, (2008)

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Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Karen L Stirrett et al Bioorg. Med. Chem. Lett. 18, 2662-8, (2008)

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Thiophene containing triarylmethanes as antitubercular agents. Maloy Kumar Parai et al Bioorg. Med. Chem. Lett. 18, 289-92, (2008)

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Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bhaskar C Das et al Bioorg. Med. Chem. Lett. 18, 3974-7, (2008)

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Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis. Xiaomei Wei et al Bioorg. Med. Chem. Lett. 18, 5448-50, (2008)

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Clubbed [1,2,3] triazoles by fluorine benzimidazole: a novel approach to H37Rv inhibitors as a potential treatment for tuberculosis. Charansingh Gill et al Bioorg. Med. Chem. Lett. 18, 6244-7, (2008)

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A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives. Gopalakrishnan Aridoss et al Bioorg. Med. Chem. Lett. 18, 6542-8, (2008)

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Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives. Robert Weis et al Bioorg. Med. Chem. 16, 10326-31, (2008)

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N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents. Umashankar Das et al Bioorg. Med. Chem. 16, 3602-7, (2008)

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Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids. Thiago M de Aquino et al Bioorg. Med. Chem. 16, 446-56, (2008)

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Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives. Ozlen Güzel et al Bioorg. Med. Chem. 16, 8976-87, (2008)

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Synthesis and anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives. Maria Cristina da Silva Lourenço et al Eur. J. Med. Chem. 43, 1344-7, (2008)

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Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides. Atul Manvar et al Eur. J. Med. Chem. 43, 2395-403, (2008)

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Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles. Sabiha Alper-Hayta et al Eur. J. Med. Chem. 43, 2568-78, (2008)

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Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives. Gülhan Turan-Zitouni et al Eur. J. Med. Chem. 43, 981-5, (2008)

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Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Anne J Lenaerts et al Antimicrob. Agents Chemother. 52, 1513-5, (2008)

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Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. Mathieu Hernould et al Antimicrob. Agents Chemother. 52, 1559-63, (2008)

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Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Hayssam Khalil et al Antimicrob. Agents Chemother. 52, 1635-41, (2008)

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Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth. Aldona L Baltch et al Antimicrob. Agents Chemother. 52, 1829-33, (2008)

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Detection of new arr-4 and arr-5 gene cassettes in clinical Pseudomonas aeruginosa and Klebsiella pneumoniae strains from Brazil. Erica Lourenço da Fonseca et al Antimicrob. Agents Chemother. 52, 1865-7, (2008)

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Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Keith Miller et al Antimicrob. Agents Chemother. 52, 1940-4, (2008)

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Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid, and rifampin. Hassan Safi et al Antimicrob. Agents Chemother. 52, 2027-34, (2008)

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Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption. Justin J Wilkins et al Antimicrob. Agents Chemother. 52, 2138-48, (2008)

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The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Silke Besier et al Antimicrob. Agents Chemother. 52, 2183-9, (2008)

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In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Gregory T Robertson et al Antimicrob. Agents Chemother. 52, 2313-23, (2008)

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Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Alita A Miller et al Antimicrob. Agents Chemother. 52, 2806-12, (2008)

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Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile. Jennifer R O'Connor et al Antimicrob. Agents Chemother. 52, 2813-7, (2008)

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Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis. R Rustomjee et al Antimicrob. Agents Chemother. 52, 2831-5, (2008)

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Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials. Rebecca Steidl et al Antimicrob. Agents Chemother. 52, 2923-5, (2008)

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Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate. Sara Marti et al Antimicrob. Agents Chemother. 52, 2955-8, (2008)

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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Feng Long et al Antimicrob. Agents Chemother. 52, 3052-60, (2008)

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Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. Martti Vaara et al Antimicrob. Agents Chemother. 52, 3229-36, (2008)

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Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. H S Heine et al Antimicrob. Agents Chemother. 52, 3350-7, (2008)

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Antagonistic effect of rifampin on the efficacy of high-dose levofloxacin in staphylococcal experimental foreign-body infection. O Murillo et al Antimicrob. Agents Chemother. 52, 3681-6, (2008)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. Donald R Hoff et al Antimicrob. Agents Chemother. 52, 4137-40, (2008)

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In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. James A Karlowsky et al Antimicrob. Agents Chemother. 52, 4163-5, (2008)

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Characterization of TolC efflux pump proteins from Pasteurella multocida. Tamas Hatfaludi et al Antimicrob. Agents Chemother. 52, 4166-71, (2008)

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Thiopurine drugs azathioprine and 6-mercaptopurine inhibit Mycobacterium paratuberculosis growth in vitro. Sung Jae Shin et al Antimicrob. Agents Chemother. 52, 418-26, (2008)

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Carbapenem-resistant Acinetobacter baumannii isolates expressing the blaOXA-23 gene associated with ISAba4 in Belgium. Pierre Bogaerts et al Antimicrob. Agents Chemother. 52, 4205-6, (2008)

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)

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Pharmacodynamics of minocycline against Staphylococcus aureus in an in vitro pharmacokinetic model. Karen E Bowker et al Antimicrob. Agents Chemother. 52, 4370-3, (2008)

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Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus. Daniel R Gentry et al Antimicrob. Agents Chemother. 52, 4507-9, (2008)

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Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan. Wenming Zhu et al Antimicrob. Agents Chemother. 52, 452-7, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Design, synthesis, and structure-activity relationships of benzophenone-based tetraamides as novel antibacterial agents. Sunil K Vooturi et al J. Med. Chem. 52, 5020-31, (2009)

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Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Markus Fridén et al J. Med. Chem. 52, 6233-43, (2009)

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Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes. Marco Pieroni et al J. Med. Chem. 52, 6287-96, (2009)

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Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles. Qingqing Huang et al J. Med. Chem. 52, 6757-67, (2009)

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From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters. Jialin Mao et al J. Med. Chem. 52, 6966-78, (2009)

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5-Nitrofuran-2-yl derivatives: synthesis and inhibitory activities against growing and dormant mycobacterium species. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 19, 1152-4, (2009)

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A microwave-assisted facile regioselective Fischer indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles. Subramanian Vedhanarayanan Karthikeyan et al Bioorg. Med. Chem. Lett. 19, 3006-9, (2009)

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Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis. Esther Del Olmo et al Bioorg. Med. Chem. Lett. 19, 5764-8, (2009)

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Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. Yasuhiro Horita et al Bioorg. Med. Chem. Lett. 19, 6313-6, (2009)

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Synthesis and biological evaluation of some new 1,4-dihydropyridines containing different ester substitute and diethyl carbamoyl group as anti-tubercular agents. Mehdi Khoshneviszadeh et al Bioorg. Med. Chem. 17, 1579-86, (2009)

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Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides. Esther Vicente et al Bioorg. Med. Chem. 17, 385-9, (2009)

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Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations. Daniele Zampieri et al Bioorg. Med. Chem. 17, 4693-707, (2009)

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Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H(37)Rv, MDR and NRP Mycobacterium tuberculosis. Ricardo Figueiredo et al Bioorg. Med. Chem. 17, 503-11, (2009)

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Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies. Sandra Gemma et al Bioorg. Med. Chem. 17, 6063-72, (2009)

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Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Songpo Guo et al Bioorg. Med. Chem. 17, 7126-30, (2009)

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A macrolactone from benzo[a]phenazine with potent activity against Mycobacterium tuberculosis. Raphael S F Silva et al Eur. J. Med. Chem. 44, 2334-7, (2009)

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Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde. P Muralidhar Reddy et al Eur. J. Med. Chem. 44, 2621-5, (2009)

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SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents. Ganesh Rajaram Jadhav et al Eur. J. Med. Chem. 44, 2930-5, (2009)

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Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides. Afshin Fassihi et al Eur. J. Med. Chem. 44, 3253-8, (2009)

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Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones. G Aridoss et al Eur. J. Med. Chem. 44, 4199-210, (2009)

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Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents. Oluseye K Onajole et al Eur. J. Med. Chem. 44, 4297-305, (2009)

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1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation. Mariangela Biava et al Eur. J. Med. Chem. 44, 4734-8, (2009)

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Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives. Suvarna G Kini et al Eur. J. Med. Chem. 44, 492-500, (2009)

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L-proline-catalysed facile green protocol for the synthesis and antimycobacterial evaluation of [1,4]-thiazines. Sethuraman Indumathi et al Eur. J. Med. Chem. 44, 4978-84, (2009)

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Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents. Tugba Ertan et al Eur. J. Med. Chem. 44, 501-10, (2009)

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Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection. Daniela Baldoni et al Antimicrob. Agents Chemother. 53, 1142-8, (2009)

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Effect of DNase and antibiotics on biofilm characteristics. George V Tetz et al Antimicrob. Agents Chemother. 53, 1204-9, (2009)

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Theileria apicoplast as a target for chemotherapy. Regina Lizundia et al Antimicrob. Agents Chemother. 53, 1213-7, (2009)

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Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs. Catherine Clark et al Antimicrob. Agents Chemother. 53, 1353-61, (2009)

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Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains. Hoang Anh Nguyen et al Antimicrob. Agents Chemother. 53, 1434-42, (2009)

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Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. Françoise Banères-Roquet et al Antimicrob. Agents Chemother. 53, 1528-31, (2009)

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Roles of NF-kappaB activation and peroxisome proliferator-activated receptor gamma inhibition in the effect of rifampin on inducible nitric oxide synthase transcription in human lung epithelial cells. Yael Yuhas et al Antimicrob. Agents Chemother. 53, 1539-45, (2009)

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Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Sara Thulin Hedberg et al Antimicrob. Agents Chemother. 53, 1561-6, (2009)

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Intracellular activity of antibiotics against Staphylococcus aureus in a mouse peritonitis model. Anne Sandberg et al Antimicrob. Agents Chemother. 53, 1874-83, (2009)

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Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance. Kozo Ochi et al Antimicrob. Agents Chemother. 53, 193-201, (2009)

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The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Joe J Harrison et al Antimicrob. Agents Chemother. 53, 2253-8, (2009)

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In vivo selection of reduced susceptibility to carbapenems in Acinetobacter baumannii related to ISAba1-mediated overexpression of the natural bla(OXA-66) oxacillinase gene. Samy Figueiredo et al Antimicrob. Agents Chemother. 53, 2657-9, (2009)

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Activity of telavancin against Staphylococcus aureus strains with various vancomycin susceptibilities in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations. Steven N Leonard et al Antimicrob. Agents Chemother. 53, 2928-33, (2009)

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Population modeling and Monte Carlo simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of rifampin in lungs. Sylvain Goutelle et al Antimicrob. Agents Chemother. 53, 2974-81, (2009)

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Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. Nicole Ritz et al Antimicrob. Agents Chemother. 53, 316-8, (2009)

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Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem. Yuki Katayama et al Antimicrob. Agents Chemother. 53, 3190-6, (2009)

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Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Wensi S Hu et al Antimicrob. Agents Chemother. 53, 3248-55, (2009)

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Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. Jose L del Pozo et al Antimicrob. Agents Chemother. 53, 35-40, (2009)

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Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. Kerstin A Wolff et al Antimicrob. Agents Chemother. 53, 3515-9, (2009)

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Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China. Wenjia Sun et al Antimicrob. Agents Chemother. 53, 3642-9, (2009)

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Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Santiago Ramón-García et al Antimicrob. Agents Chemother. 53, 3675-82, (2009)

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Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Zuzana Svetlíková et al Antimicrob. Agents Chemother. 53, 4015-8, (2009)

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Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Julian G Hurdle et al Antimicrob. Agents Chemother. 53, 4028-31, (2009)

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Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. O Murillo et al Antimicrob. Agents Chemother. 53, 4252-7, (2009)

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Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains. Rekha G Panchal et al Antimicrob. Agents Chemother. 53, 4283-91, (2009)

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New approach for drug susceptibility testing: monitoring the stress response of mycobacteria. Ronald J Rieder et al Antimicrob. Agents Chemother. 53, 4598-603, (2009)

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Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro. R J Suchland et al Antimicrob. Agents Chemother. 53, 4604-11, (2009)

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Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Yudong Liu et al Antimicrob. Agents Chemother. 53, 512-8, (2009)

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Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Vijaya Bharathi Srinivasan et al Antimicrob. Agents Chemother. 53, 5312-6, (2009)

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New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development. Jossy van den Boogaard et al Antimicrob. Agents Chemother. 53, 849-62, (2009)

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Continuous cefazolin infusion to treat bone and joint infections: clinical efficacy, feasibility, safety, and serum and bone concentrations. Valérie Zeller et al Antimicrob. Agents Chemother. 53, 883-7, (2009)

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Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro. Adam Belley et al Antimicrob. Agents Chemother. 53, 918-25, (2009)

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Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. Ericsson D Coy et al J. Nat. Prod. 72, 1245-8, (2009)

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Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. Wai S Ma et al J. Nat. Prod. 72, 1842-6, (2009)

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Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera. Suppamit Dettrakul et al J. Nat. Prod. 72, 861-5, (2009)

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Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. Shunyan Mo et al J. Nat. Prod. 72, 894-9, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. Li Liu et al J. Med. Chem. 53, 2882-91, (2010)

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3'-bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of Mycobacterium tuberculosis. Neeraj Shakya et al J. Med. Chem. 53, 4130-40, (2010)

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Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Peng, J.; et al. J. Med. Chem. 53, 61, (2010)

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Inhibition of mycobacterial replication by pyrimidines possessing various C-5 functionalities and related 2'-deoxynucleoside analogues using in vitro and in vivo models. Naveen C Srivastav et al J. Med. Chem. 53, 6180-7, (2010)

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Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents. Songpo Guo et al J. Med. Chem. 53, 649-59, (2010)

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Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development. Annamaria Lilienkampf et al J. Med. Chem. 53, 678-88, (2010)

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Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents. Sumesh Eswaran et al Bioorg. Med. Chem. Lett. 20, 1040-4, (2010)

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Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs. Mao, J.; et al. Bioorg. Med. Chem. Lett. 20, 1263, (2010)

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A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents. Subramanian Vedhanarayanan Karthikeyan et al Bioorg. Med. Chem. Lett. 20, 350-3, (2010)

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5-Nitro-2-furoic acid hydrazones: design, synthesis and in vitro antimycobacterial evaluation against log and starved phase cultures. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 20, 4313-6, (2010)

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Antitubercular potential of some semisynthetic analogues of phytol. Dharmendra Saikia et al Bioorg. Med. Chem. Lett. 20, 508-12, (2010)

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Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Jingjing Yao et al Bioorg. Med. Chem. Lett. 20, 56-9, (2010)

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A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation. Shanmugavel Uma Maheswari et al Bioorg. Med. Chem. Lett. 20, 7278-82, (2010)

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Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Renate H Hans et al Bioorg. Med. Chem. Lett. 20, 942-4, (2010)

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Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Timothy J Opperman et al Bioorg. Med. Chem. 18, 2123-30, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents. Saioa Ancizu et al Bioorg. Med. Chem. 18, 2713-9, (2010)

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines. José C Aponte et al Bioorg. Med. Chem. 18, 2880-6, (2010)

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A new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives. M Shahjahan Kabir et al Bioorg. Med. Chem. 18, 4178-86, (2010)

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Identification of novel antitubercular compounds through hybrid virtual screening approach. Muhammad Muddassar et al Bioorg. Med. Chem. 18, 6914-21, (2010)

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Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities. Compounds modified in the imidazole ring. Abhijit Datta Khoje et al Bioorg. Med. Chem. 18, 7274-82, (2010)

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Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin. Mariangela Biava et al Bioorg. Med. Chem. 18, 8076-84, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Discovery of novel antitubercular 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives. Dharmarajan Sriram et al Eur. J. Med. Chem. 45, 120-3, (2010)

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1,3-Dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines. Raju Suresh Kumar et al Eur. J. Med. Chem. 45, 124-33, (2010)

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Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters. Garrett C Moraski et al Eur. J. Med. Chem. 45, 1703-16, (2010)

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A note to the biological activity of benzoxazine derivatives containing the thioxo group. Karel Waisser et al Eur. J. Med. Chem. 45, 2719-25, (2010)

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New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties Eswaran, S.; et al. Eur. J. Med. Chem. 45, 3374, (2010)

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Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles. André P Liesen et al Eur. J. Med. Chem. 45, 3685-91, (2010)

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Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs. Kuntal Manna et al Eur. J. Med. Chem. 45, 3831-9, (2010)

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Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles. Navin B Patel et al Eur. J. Med. Chem. 45, 4293-9, (2010)

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A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents. Sailendra Singh et al Eur. J. Med. Chem. 45, 4379-82, (2010)

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Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives. Elsa Moreno et al Eur. J. Med. Chem. 45, 4418-26, (2010)

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Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. Chatchawan Changtam et al Eur. J. Med. Chem. 45, 4446-57, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines. Nimesh R Kamdar et al Eur. J. Med. Chem. 45, 5056-63, (2010)

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A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation. Prasanna, P.; et al. Eur. J. Med. Chem. 45, 5653, (2010)

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Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agents. Chiao-Li Yang et al Eur. J. Med. Chem. 45, 602-7, (2010)

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Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety. Nuray Ulusoy Güzeldemirci et al Eur. J. Med. Chem. 45, 63-8, (2010)

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New 1,3-oxazolo[4,5-c]quinoline derivatives: synthesis and evaluation of antibacterial and antituberculosis properties. Sumesh Eswaran et al Eur. J. Med. Chem. 45, 957-66, (2010)

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Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis. Hassan Safi et al Antimicrob. Agents Chemother. 54, 103-8, (2010)

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Pharmacokinetics of antituberculosis drugs in pulmonary tuberculosis patients with type 2 diabetes. Rovina Ruslami et al Antimicrob. Agents Chemother. 54, 1068-74, (2010)

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Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China. Tao Luo et al Antimicrob. Agents Chemother. 54, 1075-81, (2010)

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Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii. María E Pachón-Ibáñez et al Antimicrob. Agents Chemother. 54, 1165-72, (2010)

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Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime. S Faure et al Antimicrob. Agents Chemother. 54, 164-9, (2010)

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Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis. Marina Sánchez-Hidalgo et al Antimicrob. Agents Chemother. 54, 1684-92, (2010)

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Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis. Joaquín Rullas et al Antimicrob. Agents Chemother. 54, 2262-4, (2010)

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In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 54, 2273-5, (2010)

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In vitro activities of DC-159a, a novel fluoroquinolone, against Mycobacterium species. Areeya Disratthakit et al Antimicrob. Agents Chemother. 54, 2684-6, (2010)

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Daptomycin is effective for treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus epidermidis. C García-de-la-Mària et al Antimicrob. Agents Chemother. 54, 2781-6, (2010)

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Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. Tianyu Zhang et al Antimicrob. Agents Chemother. 54, 2806-13, (2010)

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Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Sébastien Coyne et al Antimicrob. Agents Chemother. 54, 333-40, (2010)

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A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane. Martti Vaara et al Antimicrob. Agents Chemother. 54, 3341-6, (2010)

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In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Michael J Pucci et al Antimicrob. Agents Chemother. 54, 3478-80, (2010)

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Multicenter study for defining the breakpoint for rifampin resistance in Neisseria meningitidis by rpoB sequencing. Muhamed-Kheir Taha et al Antimicrob. Agents Chemother. 54, 3651-8, (2010)

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Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Jürgen A Bohnert et al Antimicrob. Agents Chemother. 54, 3770-5, (2010)

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Different classes of antibiotics differentially influence shiga toxin production. Colleen Marie McGannon et al Antimicrob. Agents Chemother. 54, 3790-8, (2010)

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Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles. Eric L Brown et al Antimicrob. Agents Chemother. 54, 388-96, (2010)

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Oligochlorophens are potent inhibitors of Bacillus anthracis. Marie H Foss et al Antimicrob. Agents Chemother. 54, 3988-90, (2010)

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Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 54, 4009-11, (2010)

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Activities of high-dose daptomycin, vancomycin, and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm. Jorge Parra-Ruiz et al Antimicrob. Agents Chemother. 54, 4329-34, (2010)

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Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Katherine R Mariner et al Antimicrob. Agents Chemother. 54, 4506-9, (2010)

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Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. Patrick Basset et al Antimicrob. Agents Chemother. 54, 4589-95, (2010)

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vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. Xiaogang Xu et al Antimicrob. Agents Chemother. 54, 4643-7, (2010)

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Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. Alka Khanna et al Antimicrob. Agents Chemother. 54, 4789-93, (2010)

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Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)

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An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus. Longzhu Cui et al Antimicrob. Agents Chemother. 54, 5222-33, (2010)

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LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Jody L Floyd et al Antimicrob. Agents Chemother. 54, 5406-12, (2010)

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