Roxithromycin
≥90% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
Erythromycin 9-
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CAS Number 80214-83-1
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Empirical Formula (Hill Notation) C41H76N2O15
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Molecular Weight 837.05
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MDL number MFCD00214389
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PubChem Substance ID 24899369
Properties
| Related Categories | 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, |
| assay | ≥90% (HPLC) |
| suitability | suitable for 1694 per US EPA |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.
Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides1.
Application
Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila1.
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