|Related Categories||1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics,|
|suitability||suitable for 1694 per US EPA|
Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.
Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides1.
Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila1.
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Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Bruchmann J, Kirchen S, and Schwartz T Environ. Sci. Pollut. Res. Int. 20(6), 3539-49, (2013)
Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Kuroda K, Venkatakrishnan R, Salker MS, et al. Mol. Endocrinol. 27(2), 192-202, (2013)
Pathological studies on the protective effect of a macrolide antibiotic, roxithromycin, against sulfur mustard inhalation toxicity in a rat model. Gao X, Anderson DR, Brown AW, et al. Toxicol. Pathol. 39(7), 1056-64, (2011)
Pharmacokinetics of tulathromycin and its metabolite in swine administered with an intravenous bolus injection and a single gavage. Wang X, Tao YF, Huang LL, et al. J. Vet. Pharmacol. Ther. 35(3), 282-9, (2012)
Susceptibility of Ureaplasma urealyticum to tetracycline, doxycycline, erythromycin, roxithromycin, clarithromycin, azithromycin, levofloxacin and moxifloxacin. Samra Z, Rosenberg S, and Dan M J. Chemother. 23(2), 77-9, (2011)
Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro. Marjanović N, Bosnar M, Michielin F, et al. Pharmacol. Res. 63(5), 389-97, (2011)
Molecular dynamics in supercooled liquid and glassy states of antibiotics: azithromycin, clarithromycin and roxithromycin studied by dielectric spectroscopy. Advantages given by the amorphous state. Adrjanowicz K, Zakowiecki D, Kaminski K, et al. Mol. Pharm. 9(6), 1748-63, (2012)
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate. Aucamp M, Liebenberg W, Strydom SJ, et al. AAPS PharmSciTech 13(2), 467-76, (2012)
[Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility]. Zhou Y, Xu XL, Wang CP, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 25(3), 201-4, (2011)
In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs. Jones, R.N., et al. Antimicrob. Agents Chemother. 24, 209, (1983)
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