Rebeccamycin solid, ≥98% (HPLC), from Saccharothrix aerocolonigenes

Properties

Related Categories	Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibits an Enzyme, Interferes with DNA Synthesis, Mechanism of Action, R, R to Z, Spectrum of Activity, Topoisomerase I More...
biological source	from Saccharothrix aerocolonigenes
assay	≥98% (HPLC)
form	solid
storage condition	protect from light
color	yellow
solubility	DMSO: ≥3 mg/mL
	THF: soluble
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... TOP1(7150) mouse ... Prkca(18750) rat ... Prkca(24680)

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Description

Biochem/physiol Actions

Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,¹ it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.² Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.³

Price and Availability

Related Papers

1. Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J.A. et al. J. Antibiot. 40, 668, (1987)

Documents

Certificate of Analysis

R4900 - Product Information Sheet (24 KB)

Safety Information

WGK Germany

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Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription