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R4900 Sigma

Rebeccamycin

solid, ≥98% (HPLC), from Saccharothrix aerocolonigenes

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal,
biological source   from Saccharothrix aerocolonigenes
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   yellow
solubility   DMSO: ≥3 mg/mL
  THF: soluble
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Prkca(24680)

Description

Biochem/physiol Actions

Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3

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