|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal,|
|biological source||from Saccharothrix aerocolonigenes|
|storage condition||protect from light|
|solubility||DMSO: ≥3 mg/mL|
|shipped in||wet ice|
human ... TOP1(7150)|
mouse ... Prkca(18750)
rat ... Prkca(24680)
Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
2. Weitman, S., et al. J. Pediatr. Hematol. Oncol. 20, 20, (1998)
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