EMAIL THIS PAGE TO A FRIEND
R4900 Sigma

Rebeccamycin

solid, ≥98% (HPLC), from Saccharothrix aerocolonigenes

Purchase

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal,
biological source   from Saccharothrix aerocolonigenes
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   yellow
solubility   DMSO: ≥3 mg/mL
  THF: soluble
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Prkca(24680)

Description

Biochem/physiol Actions

Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent, it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc. Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.

Price and Availability


DISCOVER Bioactive Small Molecules
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?