R4900 Sigma


solid, ≥98% (HPLC), from Saccharothrix aerocolonigenes



Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal,
biological source   from Saccharothrix aerocolonigenes
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   yellow
solubility   DMSO: ≥3 mg/mL
  THF: soluble
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Prkca(24680)


Biochem/physiol Actions

Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent, it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc. Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.

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DISCOVER Bioactive Small Molecules

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Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

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