|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,|
|storage condition||protect from light|
|solubility||DMSO: soluble >10 mg/mL|
human ... IL1B(3553), TNF(7124)|
rat ... Alox5(25290)
p38 MAP kinase inhibitor.
Certificate of Analysis
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Biofiles, Central Nervous System, Diseases, Events, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions, Type
p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. Kusuhara M, Takahashi E, Peterson TE, et al. Circ. Res. 83(8), 824-31, (1998)
p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. Frasch SC, Nick JA, Fadok VA, et al. J. Biol. Chem. 273(14), 8389-97, (1998)
Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase. Pouliot M, Baillargeon J, Lee JC, et al. J. Immunol. 158(10), 4930-7, (1997)
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. Gomez-Lazaro M, Galindo MF, Concannon CG, et al. J. Neurochem. 104(6), 1599-612, (2008)
A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase. Casper D, Bukhtiyarova M, and Springman EB Anal. Biochem. 325(1), 126-36, (2004)
p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells. Kintscher U, Bruemmer D, Blaschke F, et al. Biochem. Biophys. Res. Commun. 305(3), 552-6, (2003)
Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Muscarella DE and Bloom SE Toxicol. Sci. 68(1), 82-92, (2002)
The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E(2) and interleukin-1 beta from human fetal membranes. Sullivan MH, Alvi SA, Brown NL, et al. Mol. Hum. Reprod. 8(3), 281-5, (2002)
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. Watanabe H, de Caestecker MP, and Yamada Y J. Biol. Chem. 276(17), 14466-73, (2001)
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Sodhi A, Montaner S, Patel V, et al. Cancer Res. 60(17), 4873-80, (2000)
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