Spermine tetrahydrochloride
BioReagent, for molecular biology
DOWNLOAD MSDS (PDF)Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
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CAS Number 306-67-2
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Empirical Formula (Hill Notation) C10H26N4 · 4HCl
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Molecular Weight 348.18
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Beilstein Registry Number 3911771
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EC Number 206-189-8
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MDL number MFCD00012914
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PubChem Substance ID 24899462
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Popular Documents: Product Information Sheet (PDF) | RAMAN FTIR (PDF)
Properties
| Related Categories | Bioactive Small Molecules, Cell Biology, DNA & RNA Purification, Molecular Biology, Plant Biotechnology, |
| Quality Level | PREMIUM |
| grade | for molecular biology |
| product line | BioReagent |
| mp | 310-311 °C (dec.)(lit.) |
| foreign activity | DNase, RNase, protease, NICKase, none detected |
| storage temp. | room temp |
Description
Application
Used to precipitate DNA from low salt aqueous buffers.1
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
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