Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
|Related Categories||Bioactive Small Molecules, Cell Biology, DNA & RNA Purification, Molecular Biology, Plant Biotechnology,|
|grade||for molecular biology|
|mp||310-311 °C (dec.)(lit.)|
|foreign activity||DNase, RNase, protease, NICKase, none detected|
|storage temp.||room temp|
Used to precipitate DNA from low salt aqueous buffers.1
Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/38|
|Safety Statements (Europe)||26-36|
1. Spermine precipitation of DNA. D.M. Wallace Meth. Enzymol. 152, 46, (1987)
Davis, L., et al. Basic Methods in Molecular Biology, (1986), 120
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