|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Cell Culture,|
|biological source||from Bacillus subtilis|
|assay||≥98% (HPLC and TLC)|
|CMC||7.5-20 μmol/L (depending on methods)|
Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. It is also used to study antitumor activity, activity against enveloped viruses, activity against the protoplast of Bacillus megaterium and the activity against Mycoplasma1.
Surfactin is a lipopeptide antibiotic that is composed of one β-hydroxy fatty acid, which has a long fatty acid moiety, and seven amino acids. Three of them have D configurations. It is a powerful biosurfactant that causes lysis of erythrocytes and bacteria. It is also a clotting inhibitor. Surfactin is thought to disrupt or disintegrate membranes via physicochemical interaction with the membranes1.
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Certificate of Origin
The Surfactant of Legionella pneumophila Is Secreted in a TolC-Dependent Manner and Is Antagonistic toward Other Legionella Species Catherine R. Stewart, Denise M. Burnside, et al. J. Bacteriol. 193, 5971 - 5984, (2011)
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