|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,|
|biological source||from Bacillus subtilis|
|assay||≥98% (HPLC and TLC)|
|CMC||7.5-20 μmol/L (depending on methods)|
Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. It is also used to study antitumor activity, activity against enveloped viruses, activity against the protoplast of Bacillus megaterium and the activity against Mycoplasma1.
Surfactin is a lipopeptide antibiotic that is composed of one β-hydroxy fatty acid, which has a long fatty acid moiety, and seven amino acids. Three of them have D configurations. It is a powerful biosurfactant that causes lysis of erythrocytes and bacteria. It is also a clotting inhibitor. Surfactin is thought to disrupt or disintegrate membranes via physicochemical interaction with the membranes1.
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The Surfactant of Legionella pneumophila Is Secreted in a TolC-Dependent Manner and Is Antagonistic toward Other Legionella Species Catherine R. Stewart, Denise M. Burnside, et al. J. Bacteriol. 193, 5971 - 5984, (2011)
Surfactins modulate the lateral organization of fluorescent membrane polar lipids: a new tool to study drug:membrane interaction and assessment of the role of cholesterol and drug acyl chain length. D'Auria L, Deleu M, Dufour S, et al. Biochim. Biophys. Acta 1828(9), 2064-73, (2013)
Co-production of surfactin and a novel bacteriocin by Bacillus subtilis subsp. subtilis H4 isolated from Bikalga, an African alkaline Hibiscus sabdariffa seed fermented condiment. Compaoré CS, Nielsen DS, Ouoba LI, et al. Int. J. Food Microbiol. 162(3), 297-307, (2013)
Inhibitory activity of surfactin, produced by different Bacillus subtilis subsp. subtilis strains, against Listeria monocytogenes sensitive and bacteriocin-resistant strains. Sabaté DC and Audisio MC Microbiol. Res. 168(3), 125-9, (2013)
Direct surfactin-gramicidin S antagonism supports detoxification in mixed producer cultures of Bacillus subtilis and Aneurinibacillus migulanus. Rautenbach M, Eyéghé-Bickong HA, Vlok NM, et al. Microbiology 158(Pt 12), 3072-82, (2012)
Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition. Hoefler BC, Gorzelnik KV, Yang JY, et al. Proc. Natl. Acad. Sci. U. S. A. 109(32), 13082-7, (2012)
Synergistic effect of surfactin from Bacillus subtilis C4 and Achyrocline satureioides extracts on the viability of Paenibacillus larvae. Sabaté DC, Gonzaléz MJ, Porrini MP, et al. World J. Microbiol. Biotechnol. 28(4), 1415-22, (2012)
Kinetic study of biosurfactant production by Bacillus subtilis LAMI005 grown in clarified cashew apple juice. de Oliveira DW, França IW, Félix AK, et al. Colloids Surf. B Biointerfaces 101, 34-43, (2013)
Contribution of surfactin and SwrA to flagellin expression, swimming, and surface motility in Bacillus subtilis. Ghelardi E, Salvetti S, Ceragioli M, et al. Appl. Environ. Microbiol. 78(18), 6540-4, (2012)
Improvement of surfactin production in Bacillus subtilis using synthetic wastewater by overexpression of specific extracellular signaling peptides, comX and phrC. Jung J, Yu KO, Ramzi AB, et al. Biotechnol. Bioeng. 109(9), 2349-56, (2012)
Genome shuffling of Bacillus amyloliquefaciens for improving antimicrobial lipopeptide production and an analysis of relative gene expression using FQ RT-PCR. Zhao J, Li Y, Zhang C, et al. J. Ind. Microbiol. Biotechnol. 39(6), 889-96, (2012)
Adsorption of surfactin produced from Bacillus subtilis using nonwoven PET (polyethylene terephthalate) fibrous membranes functionalized with chitosan. Behary N, Perwuelz A, Campagne C, et al. Colloids Surf. B Biointerfaces 90, 137-43, (2012)
The plant-associated Bacillus amyloliquefaciens strains MEP2 18 and ARP2 3 capable of producing the cyclic lipopeptides iturin or surfactin and fengycin are effective in biocontrol of sclerotinia stem rot disease. Alvarez F, Castro M, Príncipe A, et al. J. Appl. Microbiol. 112(1), 159-74, (2012)
The bacterial lipopeptide surfactin targets the lipid fraction of the plant plasma membrane to trigger immune-related defence responses. Henry G, Deleu M, Jourdan E, et al. Cell. Microbiol. 13(11), 1824-37, (2011)
Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity. Mizuno D, Kimoto T, Takei T, et al. Vaccine 29(33), 5368-78, (2011)
Modeling antimicrobial activity of lipopeptides from Bacillus amyloliquefaciens ES-2 against Shewanella putrefaciens in shrimp meat using a response surface method. Liu H, Sun L, Wang Y, et al. J. Food Prot. 75(10), 1855-8, (2012)
Production of polysaccharide and surfactin by Bacillus subtilis ATCC 6633 using rehydrated whey powder as the fermentation medium. Cagri-Mehmetoglu A, Kusakli S, and van de Venter M J. Dairy Sci. 95(7), 3643-9, (2012)
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