Surfactin from Bacillus subtilis, ≥98% (HPLC and TLC)

Properties

Related Categories	Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Cell Culture, Chemical Structure Class, Detergents, Detergents N to Z, Detergents by Applications, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Membrane Protein Solubilization, Peptides, Spectrum of Activity, Zwitterionic Detergents More...
biological source	from Bacillus subtilis
description	zwitterionic
assay	≥98% (HPLC and TLC)
CMC	7.5-20 μmol/L (depending on methods)
storage temp.	2-8°C

Description

Application

Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. It is also used to study antitumor activity, activity against enveloped viruses, activity against the protoplast of Bacillus megaterium and the activity against Mycoplasma¹.

Biochem/physiol Actions

Surfactin is a lipopeptide antibiotic that is composed of one β-hydroxy fatty acid, which has a long fatty acid moiety, and seven amino acids. Three of them have D configurations. It is a powerful biosurfactant that causes lysis of erythrocytes and bacteria. It is also a clotting inhibitor. Surfactin is thought to disrupt or disintegrate membranes via physicochemical interaction with the membranes¹.