Synonym: SOD, Superoxide: superoxide oxidoreductase
|Related Categories||1.15.x.x Acting on superoxide radicals, 1.x.x.x Oxidoreductases, Application Index, Biochemicals and Reagents, Cell Biology,|
|composition||Protein, 80-100% biuret|
|Gene Information||human ... SOD1(6647), SOD2(6648), SOD3(6649)|
For assay method, see McCord, J.M. and Fridovich, I., J. Biol. Chem., 244, 6049 (1969).
Catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO.3 SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.4,5
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide. Superoxide dismutase erythrocytes in newborn children have higher activity than in adults. 6
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
Lyophilized powder containing potassium phosphate buffer salts
Superoxide dismutase from human erythrocytes has been used in a study to identify in vitro glycated sites of human Cu-Zn-superoxide dismutase. 1 Superoxide dismutase from human erythrocytes has also been used in a study to investigate a prospective test-system for the screening of cytoprotective drugs and their combinations. 2
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Cell damage is induced by reactive oxygen species (ROS). ROS are either free radicals, reactive anions containing oxygen atoms, or molecules containing oxygen atoms that can either produce free radic...
BioFiles 2006, 1.5, 4.
Keywords: Aerobic, Alzheimer Disease, Bacterial conjugations, Cancer, Metabolism, Oxidations, Parkinson Disease, Reductions, Respiration
Oxidative stress is implicated in the pathogenesis of lipotoxicity in both animal and human studies. Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is ...
BioFiles 2011, 6.4, 22.
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell signaling, Cellular processes, Gene expression, Indicators, Metabolism, Oxidations, Respiratory
1. OBJECTIVE To standardize a procedure for the enzymatic determination of superoxide dismutase.
Keywords: Catalysis, Reductions
3. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Beckman, J.S., et al. Proc. Natl. Acad. Sci. U. S. A. 87, 1620-1624, (1990)
4. Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Tilly, J.L., and Tilly, K.I. Endocrinology 136, 242-252, (1995)
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