|Related Categories||Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Anticoagulants, Approved Therapeutics/Drug Candidates,|
|optical activity||[α]/D +54 to +70°, c = 0.5 in methanol|
|color||white to tan|
|solubility||DMSO: ≥20 mg/mL (warmed)|
(S)-(+)-Clopidogrel hydrogensulfate was used as standard in HPLC-MS/MS to detect clopidogrel and its thiol derivative in human plasma.1
(S)-(+)-Clopidogrel hydrogen sulfate is an antithrombotic antiplatelet agent. It specifically and irreversibly inhibits the Purinoceptor P2Y12 subtype which inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer.
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BioFiles v7 n5, 2012, 25–26
Keywords: Anticoagulants, Cardiovascular, Pharmaceutical
1. A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma. Peer CJ, Spencer SD, VanDenBerg DA, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 880(1), 132-9, (2012)
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