|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,|
|color||white to beige|
|solubility||H2O: ≥2 mg/mL at warmed to 60 °C|
SR 142948A was used to study the role of neurotensin signaling in intracellular alkanization and expression of IL-8 in human pancreatic cancer cells.1
SR 142948A is a non-peptide Neurotensin receptor antagonist
SR 142948A is a potent neurotensin receptor antagonist that affects the expression of c-Fos and has properties of antipsychotic agent. It blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concentration of Ca+2 induced by the activation of phospholipase C in CHO cell model.
Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs. Binder EB, Kinkead B, Owens MJ, et al. Biol. Psychiatry 29(12), 2200-7, (2004)
A neurotensin agonist and antagonist decrease and increase activity, respectively, but do not preclude discrete cue conditioning. Norman C, Grimond-Billa SK, Bennett GW, Cassaday HJ. J. Psychopharmacol. 3, 373-81, (2010)
Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey. Mitchell VA, Kawahara H, Vaughan CW. J. Physiol. pt 11, 2511-20, (2009)
Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Marie-Claire C, Palminteri S, Romualdi P, Noble F. Neuropharmacology 7, 1107-11, (2008)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?