|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cephalon,|
|optical activity||[α]/D -8.5 to 10°, c = 1 in H2O|
|color||white to tan|
|solubility||H2O: ≥14 mg/mL|
Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.
The selective GAT inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABAA receptor agonist gaboxadol Madsen, K.K., et al. J. Pharmacol. Exp. Ther., (2011)
Pregabalin effect on steady-state pharmacokinetics of carbamazepine, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, and tiagabine. Bockbrader, H.N., et al. Epilepsia 52, 405-409, (2011)
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