|Related Categories||Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecules, CI-CY, Cell Biology,|
|color||white to tan|
|solubility||DMSO: ≥10 mg/mL|
CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.
Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. Horrillo R, Planagumà A, González-Périz A, et al. J. Pharmacol. Exp. Ther. 323(3), 778-86, (2007)
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. Zweifel BS, Hardy MM, Anderson GD, Dufield DR, Pufahl RA, Masferrer JL. Eur. J. Pharmacol. 584, 166-174, (2008)
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