|Related Categories||Angiogenesis, Angiogenic Factors, Cancer Research, Cell Biology, Cell Signaling and Neuroscience,|
|recombinant||expressed in NSO cells|
|suitability||cell culture tested|
|Gene Information||human ... TIE1(7075)|
Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity.
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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