Tie-1/Fc Chimera human
≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested
DOWNLOAD MSDS (PDF)Synonym: Tyrosine kinase with Ig and EGF homology domains 1
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MDL number MFCD02100724
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Popular Documents: Datasheet (PDF)
Properties
| Related Categories | Angiogenesis, Angiogenic Factors, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, |
| recombinant | expressed in NSO cells |
| assay | ≥90% (SDS-PAGE) |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| suitability | cell culture tested |
| storage temp. | −20°C |
| Gene Information | human ... TIE1(7075) |
Description
Biochem/physiol Actions
Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Price and Availability
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