• USA Home
  • T8516 - Trifluoperazine dihydrochloride

EMAIL THIS PAGE TO A FRIEND

T8516 Sigma

Trifluoperazine dihydrochloride

≥99%, powder

Synonym: 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride

Properties

Related Categories Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Antagonists, Cell Biology,
assay   ≥99%
form   powder
color   white to off-white
mp   243 °C (dec.)(lit.)
solubility   ethanol: soluble5 mg/mL
  H2O: soluble50 mg/mL, clear, colorless to yellow
  DMSO: soluble
storage temp.   −20°C
Gene Information   human ... DRD2(1813)

Description

Packaging

5, 10 g in glass bottle

Preparation Note

Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml).

Application

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons1. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux2.

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


New TruPAGE™ Pre-cast Polyacrylamide Gels

Customers Also Viewed

Trifluoperazine hydrochloride

meets USP testing specifications

Trifluoperazine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?