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T8516 Sigma

Trifluoperazine dihydrochloride

≥99%, powder

Synonym: 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride


Related Categories Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Antagonists, Cell Biology,
assay   ≥99%
form   powder
color   white to off-white
mp   243 °C (dec.)(lit.)
solubility   ethanol: soluble5 mg/mL
  H2O: soluble50 mg/mL, clear, colorless to yellow
  DMSO: soluble
storage temp.   −20°C
Gene Information   human ... DRD2(1813)



5, 10 g in glass bottle

Preparation Note

Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml).


Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons1. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux2.

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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United States Pharmacopeia (USP) Reference Standard

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