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V116 Sigma

Z-VAD-FMK

solid

Synonym: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

  • Empirical Formula (Hill Notation) C22H30FN3O7

  • Molecular Weight 467.49

  •  MDL number MFCD01074990

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Description

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Caution

Hygroscopic

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability


DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

WGK Germany 
3

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers

References

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Netrin-1 is a survival factor during commissural neuron navigation. Furne C, Rama N, Corset V, Chedotal A, Mehlen P Proc. Natl. Acad. Sci. U. S. A., 14465-70, (2008)

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM Proc. Natl. Acad. Sci. U. S. A., 7437-42, (2009)

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Inhibition of interleukin1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Hara, et al. Proc. Natl. Acad. Sci. U. S. A. 94, 2007-2012, (1997)

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Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. McCarthy, et al. J. Cell Biol. 136, 215, (1997)

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Multifunctional role of Erk5 in multiple myeloma. Carvajal-Vergara X, et. al. Blood, 4492-9, (2006)

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Selective activation of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino, A.J., Patterson, S.D. J. Biol. Chem. 272, 7013, (1997)

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Apoptosis in cerebellar granule neurones: involvement of interleukin-1β converting enzyme-like proteases. Taylor, et al. J. Neurochem. 68, 1598, (1997)

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Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis. Welin A, Eklund D, Stendahl O, et al. PLoS ONE 6(5), e20302, (2011)

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ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. Zhang H, Lei Y, Yuan P, et al. PLoS ONE 9(5), e96418, (2014)

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Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Wang L Cancer Res. 68(12), 4640-8, (2008)

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Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Mercedes Lioni et al Mol. Cancer Ther. 7, 2866-75, (2010)

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Apoptosis in transgenic mice expressing the P301L mutated form of human tau. Ramalho RM Mol. Med. 14(5-6), 309-17, (2008)

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Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. Czupryna J and Tsourkas A PLoS ONE 6(5), e20073, (2011)

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