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Retention Mechanism: Cation exchange
Sample Matrix Compatibility: Organic or aqueous solutions
• A polymerically bonded, ethylenediamine triacetic acid phase with a pKa of 4.8
• Counter ion is Na+
• Ion exchange capacity is ∼ 0.15 meq/g
• Carries a negative charge at pH 6.8 or above
• A pH of 2.8 or below neutralizes this phase for easier elution of strong cationic analytes that are neutralized only at extreme basic conditions
• Typically used when dealing with very strong cationic (high pKa) compounds that may be irreversibly retained on strong cation exchangers
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