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111988 Aldrich

Ethyl 4-hydroxybenzoate

ReagentPlus®, 99%

Synonym: Ethylparaben

  • CAS Number 120-47-8

  • Linear Formula HOC6H4CO2C2H5

  • Molecular Weight 166.17

  •  Beilstein Registry Number 1101972

  •  MDL number MFCD00002353

  •  PubChem Substance ID 24847055

  •  eCl@ss 39024522

  • Popular Documents:  FTNMR (PDF)  



Related Categories Building Blocks, C8 to C9, Carbonyl Compounds, Chemical Synthesis, Esters,
grade   ReagentPlus®
assay   99%
bp   297-298 °C(lit.)
mp   114-117 °C(lit.)



100, 500 g in poly bottle

5 g in glass bottle


Ethyl 4-hydroxybenzoate (ethylparaben) was used to study the in-situ derivatisation solid-phase microextraction procedure for determining parabens, related chlorophenols, and triclosan in water1.

Ethyl 4-hydroxybenzoate, a novel sorbent for solid-phase extraction, was used to study its retention property. It has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding.

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Personal Protective Equipment 
WGK Germany 

Protocols & Articles

Peer-Reviewed Papers


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1. Trace analysis of parabens, triclosan and related chlorophenols in water by headspace solid-phase microextraction with in situ derivatization and gas chromatography-tandem mass spectrometry. Regueiro J, Becerril E, Garcia-Jares C, et al. J. Chromatogr. A. 1216(23), 4693-702, (2009)


Ampholine-functionalized hybrid organic-inorganic silica material as sorbent for solid-phase extraction of acidic and basic compounds. Wang T, Chen Y, Ma J, et al. J. Chromatogr. A. 1308, 63-72, (2013)


Do parabens have the ability to interfere with steroidogenesis? Taxvig C, Vinggaard AM, Hass U, et al. Toxicol. Sci. 106(1), 206-13, (2008)


Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)


Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. Calafat AM, Ye X, Wong LY, et al. Environ. Health Perspect. 118(5), 679-85, (2010)


Alkyl protocatechuates as novel urinary biomarkers of exposure to p-hydroxybenzoic acid esters (parabens). Wang L and Kannan K Environ. Int. 59, 27-32, (2013)


The preservatives ethyl-, propyl- and butylparaben are oestrogenic in an in vivo fish assay. Pedersen KL, Pedersen SN, Christiansen LB, et al. Pharmacol. Toxicol. 86(3), 110-3, (2000)


Ethyl-paraben and nicotinamide mixtures: apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal. Nicoli S, Bilzi S, Santi P, et al. J. Pharm. Sci. 97(11), 4830-9, (2008)


[Chemical constituents of rhizoma imperatae and their anti-complementary activity]. Fu LN, Chen LY, Liu RH, et al. Zhong Yao Cai 33(12), 1871-4, (2010)


[Quantitative determination of ethyl-p-hydroxybenzoate in resins extracted from Dracaena cochinchinensis with two technologies]. Song YY, Zhang QY, Hu YQ, et al. Zhongguo Zhong Yao Za Zhi 29(4), 323-5, (2004)


Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography-mass spectrometry. Lee MR, Lin CY, Li ZG, et al. J. Chromatogr. A. 1120(1-2), 244-51, (2006)


Use of a capillary tube for collecting an extraction solvent lighter than water after dispersive liquid-liquid microextraction and its application in the determination of parabens in different samples by gas chromatography--flame ionization detection. Farajzadeh MA, Djozan Dj, and Bakhtiyari RF Talanta 81(4-5), 1360-7, (2010)


Direct rapid analysis of multiple PPCPs in municipal wastewater using ultrahigh performance liquid chromatography-tandem mass spectrometry without SPE pre-concentration. Yu K, Li B, and Zhang T Anal. Chim. Acta 738, 59-68, (2012)


Relating solubility data of parabens in liquid PEG 400 to the behaviour of PEG 4000-parabens solid dispersions. Unga J, Tajarobi F, Norder O, et al. Eur. J. Pharm. Biopharm. 73(2), 260-8, (2009)


Assessment of principal parabens used in cosmetics after their passage through human epidermis-dermis layers (ex-vivo study). El Hussein S, Muret P, Berard M, et al. Exp. Dermatol. 16(10), 830-6, (2007)


Lack of spermatotoxic effects of methyl and ethyl esters of p-hydroxybenzoic acid in rats. Oishi S Food Chem. Toxicol. 42(11), 1845-9, (2004)


Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture. Jewell C, Prusakiewicz JJ, Ackermann C, et al. Toxicol. Appl. Pharmacol. 225(2), 221-8, (2007)


Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. Vo TT, Yoo YM, Choi KC, et al. Reprod. Toxicol. 29(3), 306-16, (2010)


Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man. Abbas S, Greige-Gerges H, Karam N, et al. Drug Metab. Pharmacokinet. 25(6), 568-77, (2010)


Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex. Pérez E, Constant P, Laval F, et al. J. Biol. Chem. 279(41), 42584-92, (2004)


Addition of perfluorocarbons to alginate hydrogels significantly impacts molecular transport and fracture stress. White JC, Stoppel WL, Roberts SC, et al. J. Biomed. Mater. Res. A 101(2), 438-46, (2013)


The effect of ethanol on the simultaneous transport and metabolism of methyl p-hydroxybenzoate in excised skin of Yucatan micropig. Oh SY, Fujii M, Takeda Y, et al. Int. J. Pharm. 236(1-2), 35-42, (2002)


Determination of ethyl-p-hydroxybenzoate in sow pancreatic juice by reversed-phase high-performance liquid chromatography. Di Giovannandre R, Diana L, Fiori M, et al. J. Chromatogr. B. Biomed. Sci. Appl. 751(2), 365-9, (2001)


Diffusion of preservatives from topical dosage forms: a comparative study. Esposito E, Bortolotti F, Nastruzzi C, et al. J. Cosmet. Sci. 54(3), 239-50, (2003)


Influence of crystal structure on the tableting properties of n-alkyl 4-hydroxybenzoate esters (parabens). Feng Y, Grant DJ, and Sun CC J. Pharm. Sci. 96(12), 3324-33, (2007)


Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben. Lemini C, Hernández A, Jaimez R, et al. Toxicol. Ind. Health 20(6-10), 123-32, (2004)


Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)


Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin. Cai Z, Song X, Sun F, et al. AAPS PharmSciTech 12(4), 1102-9, (2011)


Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells. Vad NM, Shaik IH, Mehvar R, et al. J. Pharm. Sci. 97(5), 1934-45, (2008)


Estimation of preservative concentrations in foods and their daily intake based on official inspection results in Japan in fiscal year 1998. Ishiwata H, Nishijima M, and Fukasawa Y Shokuhin Eiseigaku Zasshi 42(6), 404-12, (2001)


Merck 14,3837

Beil. 10,IV,367

Corp MSDS 1, 1908:C / FT-IR 2 (2), 2844:C / FT-IR 1 (2), 297:A / FT-NMR 1 (2), 1253:B / IR-Spectra (3), 1029:G / IR-Spectra (2), 901:F / NMR-Reference 2 (2), 286:D / RegBook 1 (2), 1905:J / Sax 6, 1562 / Sigma FT-IR 1 (2), 620:D / Structure Index 1, 305:A:5 / Vapor Phase 3, 1365:B

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32559 Ethyl 4-hydroxybenzoate-ring-13C6 solution, 50 μg/mL in acetone, analytical standard

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