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119660 Aldrich

Tris(2-chloroethyl) phosphate

97%

Synonym: Phosphoric acid tris(2-chloroethyl) ester

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Organic Phosphates/Phosphites, Phosphorus Compounds More...
vapor pressure   <10 mmHg ( 25 °C)
assay   97%
refractive index   n20/D 1.472(lit.)
bp   192 °C/10 mmHg(lit.)
solubility   H2O: soluble7.82 g/L
density   1.39 g/mL at 25 °C(lit.)

Description

Packaging

25 g in glass bottle

Application

Tris(2-chloroethyl) phosphate was used in dynamic air sampling of airborne organophosphate triesters using a solid-phase microextraction device1.

General description

Tris(2-chloroethyl) phosphate is used as a flame retardant 2in plastics, especially inflexible foams used in automobiles and furniture and in rigid foams used for building insulation3.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T,N
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45-61
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
3
RTECS 
KK2450000
Flash Point(F) 
449.6 °F
Flash Point(C) 
232 °C

Protocols & Articles

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Peer-Reviewed Papers

References

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1. Dynamic field sampling of airborne organophosphate triesters using solid-phase microextraction under equilibrium and non-equilibrium conditions. Isetun S and Nilsson U Analyst 130(1), 94-8, (2005)

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2. Toxicity and carcinogenicity of chronic exposure to tris(2-chloroethyl)phosphate. Matthews HB, Eustis SL, and Haseman J Fundam. Appl. Toxicol. 20(4), 477-85, (1993)

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3. TRIS (2-CHLOROETHYL) PHOSPHATE IARC Monographs 71, 1543-1548, (1990)

Organophosphate triesters in indoor environments. Staaf T and Ostman C J. Environ. Monit. 7(9), 883-7, (2005)

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Reproductive toxicology. Tris(2-chloroethyl)phosphate. Environ. Health Perspect. 105 Suppl 1, 365-6, (1997)

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Use of SAR in computer-assisted prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program. Enslein K, Gombar VK, and Blake BW Mutat. Res. 305(1), 47-61, (1994)

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[Effect of oral administration of tris(2-chloroethyl) phosphate to pregnant rats on prenatal and postnatal development]. Kawashima K, Tanaka S, Nakaura S, et al. Eisei Shikenjo Hokoku. (101), 55-61, (1983)

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[Studies on the co-operative effects of organic pollutants and bacterial endotoxin (LPS) on mouse liver [1]. On the simultaneous administration of carbon tetrachloride tris (2-chloroethyl) phosphate or polychlorinated biphenyls with LPS]. Hasegawa R, Kushiya M, Komuro T, et al. Eisei Shikenjo Hokoku. (105), 74-7, (1987)

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[Hygienic regulation of tri(chloroethyl)phosphate in the water]. Zaĭtsev NA and Skachkova IN Gig. Sanit. (9), 77-8, (1989)

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Tris(2-chloroethyl) phosphate. IARC Monogr. Eval. Carcinog. Risks Hum. 48, 109-20, (1990)

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Tris(2-chloroethyl) phosphate. IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3, 1543-8, (1999)

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Determination of phosphoric acid triesters in human plasma using solid-phase microextraction and gas chromatography coupled to inductively coupled plasma mass spectrometry. Shah M, Meija J, Cabovska B, et al. J. Chromatogr. A 1103(2), 329-36, (2006)

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Sources of endocrine-disrupting chemicals in urban wastewater, Oakland, CA. Jackson J and Sutton R Sci. Total Environ. 405(1-3), 153-60, (2008)

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Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum. Moore PF, Affolter VK, and Keller SM Vet. Dermatol. 24(1), 204-11.e44-5, (2013)

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Tris(2-chloroethyl)phosphate increases ambulatory activity in mice: pharmacological analyses of its neurochemical mechanism. Umezu T, Yonemoto J, Soma Y, et al. Toxicol. Appl. Pharmacol. 148(1), 109-16, (1998)

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Proapoptotic effect of a micropollutant (tris-(2-chloroethyl)-phosphate) at environmental level in primary cultured renal proximal tubule cells. Ren X, Han HJ, Lee YJ, et al. J. Water Health 10(4), 522-30, (2012)

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Chlorinated ethyl and isopropyl phosphoric acid triesters in the indoor environment--an inter-laboratory exposure study. Ingerowski G, Friedle A, and Thumulla J Indoor Air 11(3), 145-9, (2001)

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Reaction of tris(2-chloroethyl)phosphate with reduced sulfur species. Saint-Hilaire D, Ismail KZ, and Jans U Chemosphere 83(7), 941-7, (2011)

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Subchronic toxicity studies indicate that tris(2-chloroethyl)phosphate administration results in lesions in the rat hippocampus. Matthews HB, Dixon D, Herr DW, et al. Toxicol. Ind. Health 6(1), 1-15, (1990)

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Intra- and interspecific nuclear ribosomal gene variation in the two Japanese Eothenomys species, E. andersoni and E. smithii. Fujimoto A and Iwasa MA Zoolog. Sci. 27(12), 907-11, (2010)

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Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Tilson HA, Veronesi B, McLamb RL, et al. Toxicol. Appl. Pharmacol. 106(2), 254-69, (1990)

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Metabolism of tris(2-chloroethyl) phosphate in rats and mice. Burka LT, Sanders JM, Herr DW, et al. Drug Metab. Dispos. 19(2), 443-7, (1991)

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Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats. Herr DW, Sanders JM, and Matthews HB Drug Metab. Dispos. 19(2), 436-42, (1991)

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Tris(2-chloroethyl) phosphate pharmacokinetics in the Fischer 344 rat: a comparison of conventional methods and in vivo microdialysis coupled with tandem mass spectrometry. Dix K, Deterding LJ, Burka LT, et al. J. Pharm. Sci. 83(11), 1622-9, (1994)

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Complete detoxification of tris(2-chloroethyl) phosphate by two bacterial strains: Sphingobium sp. strain TCM1 and Xanthobacter autotrophicus strain GJ10. Takahashi S, Miura K, Abe K, et al. J. Biosci. Bioeng. 114(3), 306-11, (2012)

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Metabolism of the flame retardant plasticizer tris(2-chloroethyl)phosphate by human and rat liver preparations. Chapman DE, Michener SR, and Powis G Fundam. Appl. Toxicol. 17(2), 215-24, (1991)

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In vivo and in vitro biological effects of the flame retardants tris(2,3-dibromopropyl) phosphate and tris(2-chlorethyl)orthophosphate. Sala M, Gu ZG, Moens G, et al. Eur. J. Cancer Clin. Oncol. 18(12), 1337-44, (1982)

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Beil. 1,II,337

Aldrich MSDS 1, 1813:D / Corp MSDS 1 (2), 3527:D / FT-IR 1 (1), 926:C / FT-IR 2 (1), 1578:D / FT-NMR 1 (1), 1497:B / IR-Spectra (2), 493:D / IR-Spectra (3), 556:E / NMR-Reference 2 (2), 876:D / RegBook 1 (1), 1115:M / Sax 6, 711 / Structure Index 1, 173:A:1

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