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11970 Aldrich

1,3-Diphenyl-2-propenone

≥98.0% (GC)

Synonym: Benzalacetophenone, Chalcone

  • CAS Number 94-41-7

  • Linear Formula C6H5CH=CHCOC6H5

  • Molecular Weight 208.26

  •  Beilstein Registry Number 1210466

  •  EC Number 202-330-2

  •  MDL number MFCD00003082

  •  PubChem Substance ID 57646947

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Properties

Related Categories Building Blocks, C15 to C38, Carbonyl Compounds, Chemical Synthesis, Ketones,
InChI Key   DQFBYFPFKXHELB-VAWYXSNFSA-N
assay   ≥98.0% (GC)
solubility   dioxane: soluble1 g/10 mL, clear, colorless
Gene Information   rat ... Ar(24208)

Description

Packaging

100 g in poly bottle

Application

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 11970.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
FL6900000
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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