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124753 Aldrich

Succinamide

98%

Synonym: Succinic diamide

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Properties

Related Categories Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis,
assay   98%
mp   260-265 °C (dec.)(lit.)
solubility   cold water: soluble220 part
  boiling water: soluble9 part
  alcohol: insoluble
  diethyl ether: insoluble

Description

Packaging

100 g in glass bottle

Application

Succinamide has been used in the characterization of a novel biuret hydrolase from the cysteine hydrolase superfamily1. It was used as nitrogen supplement in the culture medium of Scenedesmus obliquus and green algae2.

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3

Protocols & Articles

Peer-Reviewed Papers

References

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1. A New Family of Biuret Hydrolases Involved in S-Triazine Ring Metabolism. Cameron SM, Durchschein K, Richman JE, et al. ACS Catalysis 2011(1), 1075-1082, (2011)

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2. Further studies on the utilization of aspartic acid, succinamide, and asparagine by green algae. Algéeus S. Physiol. Plant. 3(4), 370-75, (1950)

Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme. Kuo-Liang Su et al Bioorg. Med. Chem. 17, 5414-9, (2009)

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Probing the structure of a rotaxane with two-dimensional infrared spectroscopy. Larsen OF, Bodis P, Buma WJ, et al. Proc. Natl. Acad. Sci. U. S. A. 102(38), 13378-82, (2005)

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Installation of a ratchet tooth and pawl to restrict rotation in a cyclodextrin rotaxane. Onagi H, Blake CJ, Easton CJ, et al. Chemistry 9(24), 5978-88, (2003)

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IR spectroscopy on jet-cooled isolated two-station rotaxanes. Rijs AM, Kay ER, Leigh DA, et al. J. Phys. Chem. A 115(34), 9669-75, (2011)

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[Derivatives of succinic acid. II. Synthesis and hypoglycemic properties of various derivatives of N-(benzenesulfonyl)succinamide]. Brzozowski Z, Gajewski F, Kozakiewicz I, et al. Acta Pol. Pharm. 42(3), 244-50, (1985)

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[Antihypoxant activity in a series of 2-aminothiazole homologs]. Marysheva VV and Shabanov PD Eksp. Klin. Farmakol. 68(1), 67-70, (2005)

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Melanocortin-4 receptor agonists for the treatment of obesity. Boyce RS and Duhl DM Curr. Opin. Investig. Drugs 5(10), 1063-71, (2004)

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The purified colicin S8 is a multimeric protein. Concepción Curbelo JL and Garcia Diaz ME Int. Microbiol. 3(4), 239-45, (2000)

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Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Lin Y, Weissleder R, and Tung CH Bioconjug. Chem. 13(3), 605-10, (2002)

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Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection. Dzeja PP, Bast P, Ozcan C, et al. Am. J. Physiol. Heart Circ. Physiol. 284(4), H1048-56, (2003)

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A multifunctional single-attachment-point reagent for controlled protein biotinylation. Garanger E, Weissleder R, and Josephson L Bioconjug. Chem. 20(1), 170-3, (2009)

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Functionalized mesoporous silicon for targeted-drug-delivery. Tabasi O, Falamaki C, and Khalaj Z Colloids Surf. B Biointerfaces 98, 18-25, (2012)

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Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core. Bioorg. Med. Chem. Lett. 14, 377, (2004)

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A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model. Priest BT, Garcia ML, Middleton RE, et al. Biochemistry 43(30), 9866-76, (2004)

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Structure analysis reveals the flexibility of the ADAMTS-5 active site. Shieh HS, Tomasselli AG, Mathis KJ, et al. Protein Sci. 20(4), 735-44, (2011)

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Adaptable synthesis of C-glycosidic multivalent carbohydrates and succinamide-linked derivatization. Miller GJ and Gardiner JM Org. Lett. 12(22), 5262-5, (2010)

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Synthesis of novel succinamide derivatives having the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. I. Watanabe T, Kinoyama I, Kakefuda A, et al. Chem. Pharm. Bull. 45(6), 996-1007, (1997)

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Synthesis of novel succinamide derivatives having a 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. II. Watanabe T, Kakefuda A, Kinoyama I, et al. Chem. Pharm. Bull. 45(9), 1458-69, (1997)

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Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries. Pirrung MC and Park K Bioorg. Med. Chem. Lett. 10(18), 2115-8, (2000)

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The effect of RMP-7 and its derivative on transporting Evans blue liposomes into the brain. Zhang X, Xie Y, Jin Y, et al. Drug Deliv. 11(5), 301-9, (2004)

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Novel P2-P4 macrocyclic inhibitors of HCV NS3/4A protease by P3 succinamide fragment depeptidization strategy. Pompei M, Di Francesco ME, Pesci S, et al. Bioorg. Med. Chem. Lett. 20(1), 168-74, (2010)

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Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Chatterjee AK, Liu H, Tully DC, et al. Bioorg. Med. Chem. Lett. 17(10), 2899-903, (2007)

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DFT studies of structure and vibrational frequencies of isotopically substituted diamin uranyl nitrate using relativistic effective core potentials. Soto CA, Carauta AN, and Carneiro JW Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 71(3), 1140-5, (2008)

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Isolation, structure determination and antibacterial activities of succinamide conjugate diacid from Acinetobacter sp. BJ-L. Wu D, Chang H, Wang Y, et al. Microbiol. Res. 166(3), 155-60, (2011)

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Merck 14,8866

Beil. 2,IV,1922

Aldrich MSDS 1, 1624:A / Corp MSDS 1 (2), 3188:B / FT-IR 2 (1), 1292:C / FT-IR 1 (1), 767:D / IR-Spectra (3), 448:D / IR-Spectra (2), 396:D / RegBook 1 (1), 901:D / Structure Index 1, 138:D:5

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