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125504 Aldrich

Cyclopropylamine

98%

Synonym: Aminocyclopropane

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Properties

Related Categories Amines, Building Blocks, C2 to C5, Chemical Synthesis, Nitrogen Compounds,
vapor pressure   4.67 psi ( 20 °C)
InChI Key   HTJDQJBWANPRPF-UHFFFAOYSA-N
assay   98%
autoignition temp.   527 °F
refractive index   n20/D 1.420(lit.)
bp   49-50 °C(lit.)
density   0.824 g/mL at 25 °C(lit.)

Description

Packaging

10, 25 g in ampule

Application

Cyclopropylamine(CPA) has been used in the synthesis of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It has been used in the synthesis of Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.

Biochem/physiol Actions

Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2733PSN1 8(3) / PGII
WGK Germany 
2
RTECS 
GZ0685500
Flash Point(F) 
33.8 °F
Flash Point(C) 
1 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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