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128724 Aldrich

7-Hydroxy-4-methylcoumarin

97%

Synonym: 4-Methylumbelliferone, 4-MU, Coumarin 4

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Properties

assay   97%
mp   188.5-190 °C(lit.)
absorption   λmax 221 nm

Description

Application

Standard for the fluorometric determination of enzyme activity.1

Suitable as laser dye

Other Notes

This product has been replaced by M1381-ALDRICH | 4-Methylumbelliferone ≥98%

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26
WGK Germany 
2
RTECS 
GN7000000

Protocols & Articles

Peer-Reviewed Papers

References

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1. Preparation and application of a fluorogenic substrate for endo-beta-xylosidase. K. Takagaki et al. J. Biochem. Biophys. Methods 19, 207, (1989)

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Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. Nadia Touisni et al J. Med. Chem. 54, 8271-7, (2011)

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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Gavin J Williams et al Nat. Chem. Biol. 3, 657-62, (2007)

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Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships. Adriana Chilin et al J. Med. Chem. 51, 752-9, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives. Juri M Timonen et al Eur. J. Med. Chem. 46, 3845-50, (2011)

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Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. Yuan Shi et al Bioorg. Med. Chem. Lett. 21, 956-60, (2011)

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Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. Maria E Riveiro et al Bioorg. Med. Chem. 16, 2665-75, (2008)

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Effect of different C3-aryl substituents on the antioxidant activity of 4-hydroxycoumarin derivatives. Sergio A Rodríguez et al Bioorg. Med. Chem. 19, 6233-8, (2011)

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Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer. Koichiro Harada et al Bioorg. Med. Chem. Lett. 20, 272-5, (2010)

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Virtual screening against nuclear factor ?B (NF-?B) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-?B dependent biological functions involved in cystic fibrosis. Laura Piccagli et al Bioorg. Med. Chem. 18, 8341-9, (2010)

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6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Atsushi Kato et al Bioorg. Med. Chem. Lett. 20, 5630-3, (2010)

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Synthesis and pharmacological activity of O-aminoalkyl derivatives of 7-hydroxycoumarin. Joanna Trykowska Konc et al Eur. J. Med. Chem. 46, 2252-63, (2011)

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Merck 14,4854

Beil. 18,V,1,439

Aldrich MSDS 1, 1067:B / Corp MSDS 1 (1), 1937:C / FT-IR 1 (2), 325:C / FT-IR 2 (2), 2911:A / FT-NMR 1 (2), 1316:A / IR-Spectra (2), 913:G / IR-Spectra (3), 1045:C / NMR-Reference 2 (2), 309:D / RegBook 1 (2), 1945:C / Sax 6, 1860 / Sigma FT-IR 1 (2), 167:A / Stains and Dyes Ref, 399 / Structure Index 1, 313:C:1

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M1381 4-Methylumbelliferone, ≥98%

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