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129453 Aldrich

3-Indoleacetonitrile

98%

Synonym: (3-Indolyl)acetonitrile, 3-(Cyanomethyl)indole, IAN, Indolylacetonitrile, NSC 523272

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Properties

Related Categories Building Blocks, C10, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
assay   98%
bp   157-160 °C/0.2 mmHg(lit.)
mp   33-36 °C(lit.)

Description

Packaging

5, 25 g in glass bottle

Application

Reactant for preparation of:
• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Histone deacetylase inhibitors
• Potential kinase inhibitors
• Kv7/KCNQ potassium channel activators
• Kinesin-Specific MKLP-2 Inhibitor
• Pesticides
• Potential PET cancer imaging agents
• Agonists of the Farnesoid X Receptor (FXR) as atherosclerosis treatment
• Butyrylcholinesterase inhibitors
• Necroptosis inhibitors

General description

3-Indoleacetonitrile (Indolylacetonitrile) is a light-induced auxin-inhibitory substance that is isolated from light-grown cabbage (Brassica olearea L.) shoots. It inhibits the biofilm formation of both E. coli O157:H7 and P. aeruginosa without affecting its growth.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
233.6 °F
Flash Point(C) 
112 °C
Protocols & Articles

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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