135380 Aldrich



Synonym: Benzyl methyl ketone, Phenyl-2-propanone

  • CAS Number 103-79-7

  • Linear Formula C6H5CH2COCH3

  • Molecular Weight 134.18

  •  Beilstein Registry Number 742120

  •  EC Number 203-144-4

  •  MDL number MFCD00017249



Related Categories Building Blocks, C9, Carbonyl Compounds, Chemical Synthesis, Ketones,
assay   99%
drug control   USDEA Schedule II
availability   available only in EU
density   1.003 g/mL at 20 °C(lit.)


General description

Phenylacetone is the immediate precursor for clandestine production of amphetamine and methamphetamine1. Phenylacetone on anaerobic incubations with rat liver mitochondria gets reduced to phenylisopropanol2.

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Safety & Documentation

Safety Information

WGK Germany 
Flash Point(F) 
194 °F
Flash Point(C) 
90 °C


Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers


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1. Comparative analysis of 1-phenyl-2-propanone (P2P), an amphetamine-type stimulant precursor, using stable isotope ratio mass spectrometry: presented in part as a poster at the 2nd meeting of the Joint European Stable Isotope User Meeting (JESIUM), Giens, France, September 2008. Schneiders S, Holdermann T, and Dahlenburg R Sci. Justice 49(2), 94-101, (2009)


2. [Biotransformation of amphetamine derivatives by rat liver mitochondria/2nd communication; Oxidative deamination of amphetamine and reduction of phenylacetone]. Blume H Arzneimittelforschung 31(6), 994-7, (1981)


Crystal structure of a Baeyer-Villiger monooxygenase. Malito E, Alfieri A, Fraaije MW, et al. Proc. Natl. Acad. Sci. U. S. A. 101(36), 13157-62, (2004)


Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization. Orru R, Dudek HM, Martinoli C, et al. J. Biol. Chem. 286(33), 29284-91, (2011)


The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase. Fraaije MW, Kamerbeek NM, Heidekamp AJ, et al. J. Biol. Chem. 279(5), 3354-60, (2004)


Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis. Dudek HM, de Gonzalo G, Pazmiño DE, et al. Appl. Environ. Microbiol. 77(16), 5730-8, (2011)


Blending Baeyer-Villiger monooxygenases: using a robust BVMO as a scaffold for creating chimeric enzymes with novel catalytic properties. van Beek HL, de Gonzalo G, and Fraaije MW Chem. Commun. (Camb.) 48(27), 3288-90, (2012)


The analysis of substituted cathinones. Part 2: an investigation into the phenylacetone based isomers of 4-methylmethcathinone and N-ethylcathinone. McDermott SD, Power JD, Kavanagh P, et al. Forensic Sci. Int. 212(1-3), 13-21, (2011)


Investigating the coenzyme specificity of phenylacetone monooxygenase from Thermobifida fusca. Dudek HM, Torres Pazmiño DE, Rodríguez C, et al. Appl. Microbiol. Biotechnol. 88(5), 1135-43, (2010)


Exploring the structural basis of substrate preferences in Baeyer-Villiger monooxygenases: insight from steroid monooxygenase. Franceschini S, van Beek HL, Pennetta A, et al. J. Biol. Chem. 287(27), 22626-34, (2012)


Impurity profiling/comparative analyses of samples of 1-phenyl-2-propanone. Krawczyk W, Kunda T, Perkowska I, et al. Bull. Narc. 57(1-2), 33-62, (2005)


Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase. Wu S, Acevedo JP, and Reetz MT Proc. Natl. Acad. Sci. U. S. A. 107(7), 2775-80, (2010)


Impurities in illicit amphetamine: review. Sinnema A and Verweij AM Bull. Narc. 33(3), 37-54, (1981)


Comparison of amphetamine metabolism using isolated hepatocytes from five species including human. Green CE, LeValley SE, and Tyson CA J. Pharmacol. Exp. Ther. 237(3), 931-6, (1986)


A stepwise approach for the reproducible optimization of PAMO expression in Escherichia coli for whole-cell biocatalysis. van Bloois E, Dudek HM, Duetz WA, et al. BMC Biotechnol. 12, 31, (2012)


Improvement of the biocatalytic properties of one phenylacetone monooxygenase mutant in hydrophilic organic solvents. de Gonzalo G, Rodríguez C, Rioz-Martínez A, et al. Enzyme Microb. Technol. 50(1), 43-9, (2012)


A re-examination of the mono-methoxy positional ring isomers of amphetamine, methamphetamine and phenyl-2-propanone. Dal Cason TA Forensic Sci. Int. 119(2), 168-94, (2001)


The effects of cofactor and species differences on the in vitro metabolism of propiophenone and phenylacetone. Coutts RT, Prelusky DB, and Jones GR Can. J. Physiol. Pharmacol. 59(2), 195-201, (1981)


CE assay for simultaneous determination of charged and neutral impurities in dexamphetamine sulfate using a dual CD system. Wongwan S, Sungthong B, and Scriba GK Electrophoresis 31(9), 1475-81, (2010)


A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase mutant derivative highly active and stereoselective on phenylacetone and benzylacetone. Ziegelmann-Fjeld KI, Musa MM, Phillips RS, et al. Protein Eng. Des. Sel. 20(2), 47-55, (2007)


Microbial degradation of illicit drugs, their precursors, and manufacturing by-products: implications for clandestine drug laboratory investigation and environmental assessment. Janusz A, Kirkbride KP, Scott TL, et al. Forensic Sci. Int. 134(1), 62-71, (2003)


Rotational spectra and conformational structures of 1-phenyl-2-propanol, methamphetamine, and 1-phenyl-2-propanone. Tubergen MJ, Lavrich RJ, Plusquellic DF, et al. J. Phys. Chem. A 110(49), 13188-94, (2006)


Analysis of the infrared and Raman spectra of the symmetrically substituted 1,3-diphenylurea and 1,3-diphenylacetone (dibenzyl ketone). Badawi HM and Förner W Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 95, 435-41, (2012)


New chiral phosphoramidite complexes of iron as catalytic precursors in the oxidation of activated methylene groups. Shejwalkar P, Rath NP, and Bauer EB Molecules 15(4), 2631-50, (2010)


The clandestine drug laboratory situation in the United States. Frank RS J. Forensic Sci. 28(1), 18-31, (1983)


Merck 14,7269

Beil. 7,IV,687

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