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138630 Aldrich

1-Chloro-2,4-dinitrobenzene

97%

Synonym: 2,4-Dinitrochlorobenzene, CDNB, DNCB

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Properties

Related Categories Building Blocks, Chemical Synthesis, Nitro Compounds, Nitrogen Compounds, Organic Building Blocks More...
InChI Key   VYZAHLCBVHPDDF-UHFFFAOYSA-N
assay   97%
expl. lim.   22 %
bp   315 °C(lit.)
mp   48-50 °C(lit.)
solubility   alcohol: soluble (hot)
  alcohol: very slightly soluble (cold)
  benzene: soluble
  carbon disulfide: soluble
  diethyl ether: soluble
  water: insoluble

Description

Packaging

5, 100, 500 g in glass bottle

Preparation Note

The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.

Application

1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes.

Biochem/physiol Actions

2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Signal word 
Danger
RIDADR 
UN 3441 6.1 / PGII
WGK Germany 
2
RTECS 
CZ0525000
Flash Point(F) 
381.2 °F
Flash Point(C) 
194 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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