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138630 Aldrich

1-Chloro-2,4-dinitrobenzene

97%

Synonym: 2,4-Dinitrochlorobenzene, CDNB, DNCB

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Properties

Related Categories Building Blocks, Chemical Synthesis, Nitro Compounds, Nitrogen Compounds, Organic Building Blocks More...
InChI Key   VYZAHLCBVHPDDF-UHFFFAOYSA-N
assay   97%
expl. lim.   22 %
bp   315 °C(lit.)
mp   48-50 °C(lit.)
solubility   alcohol: soluble (hot)
  alcohol: very slightly soluble (cold)
  benzene: soluble
  carbon disulfide: soluble
  diethyl ether: soluble
  water: insoluble

Description

Packaging

5, 100, 500 g in glass bottle

Preparation Note

The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.

Application

1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes.

Biochem/physiol Actions

2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Signal word 
Danger
RIDADR 
UN 3441 6.1 / PGII
WGK Germany 
2
RTECS 
CZ0525000
Flash Point(F) 
381.2 °F
Flash Point(C) 
194 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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