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139858 Aldrich

6-Methoxyindole

98%

Synonym: NSC 92517

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Properties

Related Categories Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   QJRWYBIKLXNYLF-UHFFFAOYSA-N
assay   98%
mp   90-92 °C(lit.)

Description

Packaging

500 mg in glass insert

Application

• Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Reactant for synthesis of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors
• Reactant for preparation of diindolyloxyindoles as anticancer agents
• Reactant for preparation of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors
• Reactant for preparation of 3-aroylindoles as anticancer agents
• Reactant for preparation of indolyl and isoquinolinyl anthranilates as PPARδ partial agonists
• Reactant for preparation of heteroaryl ketones as VEGFR-2 inhibitors

6-Methoxyindole was used to study the fluorescence of protonated excited-state forms of serotonin and other related compounds in acid. It was used in the preparation of:
• tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, potential anticancer immunomodulator
• indolylindazoles and indolylpyrazolopyridines, interleukin-2 inducible T cell kinase inhibitors
• diindolyloxyindoles, anticancer agents
• benzoylpiperazinyl-indolyl ethane dione derivatives, HIV-1 inhibitors
• 3-aroylindoles as anticancer agents
• indolyl and isoquinolinyl anthranilates, PPARδ partial agonists
• heteroaryl ketones, VEGFR-2 inhibitors

Biochem/physiol Actions

6-Methoxyindole inhibits the chlorinating activity of myeloperoxidase and inhibits the generation of hypochlorous acid released by activated leukocytes.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Indoles

Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Applications, Building blocks, Cardiovascular, Chemfiles, Company, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory

Peer-Reviewed Papers
15

References

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