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144657 Aldrich

Trifluoroacetamide

97%

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Properties

Related Categories Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis,
assay   97%
bp   162.5 °C(lit.)
mp   65-70 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies1.

General description

Trifluoroacetamide is a good quencher of tryptophan fluorescence2.

Price and Availability

Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3

Protocols & Articles

Peer-Reviewed Papers

References

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1. Determination of membrane potential and cell volume by 19F NMR using trifluoroacetate and trifluoroacetamide probes. London RE and Gabel SA Biochemistry 28(6), 2378-82, (1989)

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2. Fluorescence quenching of tryptophan by trifluoroacetamide. Midoux P, Wahl P, Auchet JC, et al. Biochim. Biophys. Acta 801(1), 16-25, (1984)

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Selective cross-coupling of organic halides with allylic acetates. Anka-Lufford LL, Prinsell MR, and Weix DJ J. Org. Chem. 77(22), 9989-10000, (2012)

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Dual activation in asymmetric allylsilane addition to chiral N-acylhydrazones: method development, mechanistic studies, and elaboration of homoallylic amine adducts. Friestad GK, Korapala CS, and Ding H J. Org. Chem. 71(1), 281-9, (2006)

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Development of a diversity-oriented approach to oxazole-5-amide libraries. Thompson MJ, Adams H, and Chen B J. Org. Chem. 74(10), 3856-65, (2009)

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Measurement of the diffusion of 2,2,2-trifluoroacetamide within thermoresponsive hydrogels using NMR imaging. Dinarvand R, Wood B, and D'Emanuele A Pharm. Res. 12(9), 1376-9, (1995)

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Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts. Hayden PJ, Ichimura T, McCann DJ, et al. J. Biol. Chem. 266(28), 18415-8, (1991)

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Determination of chloride potential in perfused rat hearts by nuclear magnetic resonance spectroscopy. Ramasamy R, Zhao P, Gitomer WL, et al. Am. J. Physiol. 263(6 Pt 2), H1958-62, (1992)

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Modulation of the antioxidant activity of HO* scavengers by albumin binding: a 19F-NMR study. Aime S, Digilio G, Bruno E, et al. Biochem. Biophys. Res. Commun. 307(4), 962-6, (2003)

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Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups. Khalaf AI, Bourdin C, Breen D, et al. Eur. J. Med. Chem. 56, 39-47, (2012)

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Peroxynitrite modification of protein thiols: oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase. Viner RI, Williams TD, and Schöneich C Biochemistry 38(38), 12408-15, (1999)

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Photochemical functionalization of gallium nitride thin films with molecular and biomolecular layers. Kim H, Colavita PE, Metz KM, et al. Langmuir 22(19), 8121-6, (2006)

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Electrochemistry in deep eutectic solvents. Nkuku CA and LeSuer RJ J. Phys. Chem. B 111(46), 13271-7, (2007)

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An efficient synthesis of GDP-hexanolamine, a key tool for the purification of fucosyltransferases. Vincent SP and Gastinel LN Carbohydr. Res. 337(11), 1039-42, (2002)

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Synthesis of fructofuranosides: efficient glycosylation with N-phenyltrifluoroacetimidate as the leaving group. Lian G, Gao Q, and Lin F Carbohydr. Res. 343(17), 2992-6, (2008)

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cis-Jasmone induces accumulation of defence compounds in wheat, Triticum aestivum. Moraes MC, Birkett MA, Gordon-Weeks R, et al. Phytochemistry 69(1), 9-17, (2008)

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First O-glycosylation of hydroxamic acids. Thomas M, Gesson JP, and Papot S J. Org. Chem. 72(11), 4262-4, (2007)

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Synthesis of carbazoles via an intramolecular cyclization of 2-(6-substituted 3(Z)-hexen-1,5-diynyl)anilines and their related molecules. Lee CY, Lin CF, Lee JL, et al. J. Org. Chem. 69(6), 2106-10, (2004)

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Aryl C-glycosylation of phenols with glycosyl trifluoroacetimidates. Li Y, Wei G, and Yu B Carbohydr. Res. 341(16), 2717-22, (2006)

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SAR study of 2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepines as progesterone receptor agonists. Dols PP, Folmer BJ, Hamersma H, et al. Bioorg. Med. Chem. Lett. 18(4), 1461-7, (2008)

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The behaviour of deoxyhexose trihaloacetimidates in selected glycosylations. Comegna D, Bedini E, Di Nola A, et al. Carbohydr. Res. 342(8), 1021-9, (2007)

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Analysis of sibutramine metabolites as N-trifluoroacetamide and O-trimethylsilyl derivatives by gas chromatography-mass spectrometry in urine. Sardela VF, Motta MT, Padilha MC, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(27), 3003-11, (2009)

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Comparison of derivatives for determination of codeine and morphine by gas chromatography/mass spectrometry. Chen BH, Taylor EH, and Pappas AA J. Anal. Toxicol. 14(1), 12-7, (1990)

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Enols as potent antibacterial agents. Thorarensen A, Zurenko GE, Sweeney MT, et al. Bioorg. Med. Chem. Lett. 11(22), 2931-4, (2001)

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1H-nuclear magnetic resonance spectroscopy of reducing-residue anomeric protons of pertrifluoroacetylated carbohydrates. Summerfelt ST, Selosse EJ, Reilly PJ, et al. Carbohydr. Res. 203(2), 163-72, (1990)

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Bulk magnetic susceptibility induced broadening in the 19F NMR of suspended leukemic cells. Adebodun F and Post JF NMR Biomed. 6(2), 125-9, (1993)

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Beil. 2,IV,471

Aldrich MSDS 1, 1755:D / Corp MSDS 1 (2), 3438:B / FT-IR 2 (1), 1260:A / FT-IR 1 (1), 752:B / FT-NMR 1 (1), 1223:B / IR-Spectra (2), 389:E / IR-Spectra (3), 439:G / RegBook 1 (1), 879:F / Structure Index 1, 134:D:5 / Vapor Phase 3, 778:C

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