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145637 Aldrich

Biochanin A

Synonym: 5,7-Dihydroxy-4′-methoxyisoflavone, Genistein 4′-methyl ether

  • CAS Number 491-80-5

  • Empirical Formula (Hill Notation) C16H12O5

  • Molecular Weight 284.26

  •  Beilstein Registry Number 278107

  •  EC Number 207-744-7

  •  MDL number MFCD00006839

  • Popular Documents:  FTNMR (PDF)  

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Properties

InChI Key   WUADCCWRTIWANL-UHFFFAOYSA-N
mp   210-213 °C(lit.)

Description

Biochem/physiol Actions

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers
15

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