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15149 Aldrich

N,N-Bis(phosphonomethyl)glycine

≥98.0% (T)

Synonym: N-(Carboxymethyl)iminodi(methylphosphinic acid), Glyphosine

  • CAS Number 2439-99-8

  • Empirical Formula (Hill Notation) C4H11NO8P2

  • Molecular Weight 263.08

  •  Beilstein Registry Number 1884944

  •  EC Number 219-468-4

  •  MDL number MFCD00056670

  •  PubChem Substance ID 329750747

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Phosphonic/Phosphinic Acids, Phosphorus Compounds More...
InChI Key   OXHDYFKENBXUEM-UHFFFAOYSA-N
assay   ≥98.0% (T)

Description

Biochem/physiol Actions

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Packaging

10, 50 g in poly bottle

Application

Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.†

General description

N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3261 8 / PGIII
WGK Germany 
1
RTECS 
MB9120000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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