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151882 Aldrich

Deuterium oxide

99.9 atom % D

Synonym: Heavy water, Water-d2

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Properties

Related Categories Alphabetical Listings, Biomolecular NMR, D, Deuterium oxide, Minimal Media Components,
isotopic purity   99.9 atom % D
refractive index   n20/D 1.328(lit.)
bp   101.4 °C(lit.)
mp   3.8 °C(lit.)
density   1.107 g/mL at 25 °C(lit.)

Description

Frequently Asked Questions

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Packaging

1 L in glass bottle

1, 4 kg in glass bottle

10×0.6, 10×0.75, 10×1 mL in ampule

10, 25, 100, 250, 500 g in glass bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Stable Isotope

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Safety & Documentation

Safety Information

WGK Germany 
3
RTECS 
ZC0230000

Protocols & Articles

Articles

Isotopic Labeling in Solid-state NMR of Proteins

ISOTEC Stable Isotopes: Resonating with the Advancing Field of Biomolecular NMR (1.21 Mb PDF)
Francesca M. Marassi, Ph.D.
ISOTEC® Stable Isotopes: Resonating with the Advancing Field of Biomolecular NMR, 2–3
Keywords: Asymmetric synthesis, Molecular biology, Nuclear magnetic resonance spectroscopy, Spectroscopy

Solid-state NMR on Larger Biomolecules

In the last years, remarkable progress has been made to probe molecular structure of biological systems using Magic Angle Spinning solid-state NMR (ssNMR). Prominent examples relate to research areas...
Marc Baldus
ISOTEC® Stable Isotopes: Products for Solid State NMR, 2010, 2–4
Keywords: Atomic absorption spectroscopy, Biochemistry, Biological processes, Catalysis, Cell biology, Gene expression, Mass spectrometry, Materials Science, Microscopy, Molecular biology, Nuclear magnetic resonance spectroscopy, Photosynthesis, Polymorphisms, Reductions, Research areas, Sample preparations, Scanning electron microscopy

Peer-Reviewed Papers

References

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Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria. Kasumov T, Dabkowski ER, Shekar KC, et al. Am. J. Physiol. Heart Circ. Physiol. 304(9), H1201-14, (2013)

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Colloidal aggregation in microgravity by critical Casimir forces. Veen SJ, Antoniuk O, Weber B, et al. Phys. Rev. Lett. 109(24), 248302, (2012)

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Moderate hyperventilation during intravenous anesthesia increases net cerebral lactate efflux. Grüne F, Kazmaier S, Sonntag H, et al. Anesthesiology 120(2), 335-42, (2014)

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Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans. Westera L, Drylewicz J, den Braber I, et al. Blood 122(13), 2205-12, (2013)

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Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus. Cherezov, V Structure 16(9), 1378-88, (2008)

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Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans. Holm L, O'Rourke B, Ebenstein D, et al. Am. J. Physiol. Endocrinol. Metab. 304(8), E895-907, (2013)

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Contrast recognizability during brilliant blue G - and heavier-than-water brilliant blue G-assisted chromovitrectomy: a quantitative analysis. Henrich PB, Valmaggia C, Lang C, et al. Acta Ophthalmol. 91(2), e120-4, (2013)

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[Application for therapeutic use of deuterium oxide (D2O) against human pancreatic cancer]. Omori H, Nio Y, Takeda H, et al. Gan To Kagaku Ryoho. 23(12), 1665-8, (1996)

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Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. Lee JJ, Lambert JE, Hovhannisyan Y, et al. Am. J. Clin. Nutr. 101(1), 34-43, (2015)

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Oxidative uncoupling in cysteine dioxygenase is gated by a proton-sensitive intermediate. Crowell JK, Li W, and Pierce BS Biochemistry 53(48), 7541-8, (2014)

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Structural characterization of membrane proteins and peptides by FTIR and ATR-FTIR spectroscopy. Tatulian SA Methods Mol. Biol. 974, 177-218, (2013)

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Examining protein-lipid complexes using neutron scattering. Clifton LA, Neylon C, and Lakey JH Methods Mol. Biol. 974, 119-50, (2013)

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Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers. Westera L, Zhang Y, Tesselaar K, et al. Methods Mol. Biol. 979, 107-31, (2013)

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Accessibility of cellulose: Structural changes and their reversibility in aqueous media. Pönni R, Kontturi E, and Vuorinen T Carbohydr. Polym. 93(2), 424-9, (2013)

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High resolution spectroscopy of the Ar-D2O and Ar-HDO molecular complexes in the near-infrared range. Didriche K and Földes T J. Chem. Phys. 138(10), 104307, (2013)

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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. Lam MP, Wang D, Lau E, et al. J. Clin. Invest. 124(4), 1734-44, (2014)

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D2O solvent isotope effects suggest uniform energy barriers in ribulose-1,5-bisphosphate carboxylase/oxygenase catalysis. Tcherkez GG, Bathellier C, Stuart-Williams H, et al. Biochemistry 52(5), 869-77, (2013)

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Self-assembly between dicarboxylate ions and binuclear europium complexes: moving to water-pH dependence and effects of buffers. Hill LR, Sørensen TJ, Blackburn OA, et al. Dalton Trans. 42(1), 67-70, (2013)

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Site-specific coupling of hydration water and protein flexibility studied in solution with ultrafast 2D-IR spectroscopy. King JT and Kubarych KJ J. Am. Chem. Soc. 134(45), 18705-12, (2012)

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Where do roots take up water? Neutron radiography of water flow into the roots of transpiring plants growing in soil. Zarebanadkouki M, Kim YX, and Carminati A New Phytol. 199(4), 1034-44, (2013)

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Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice. Drake JC, Peelor FF, Biela LM, et al. J. Gerontol. A. Biol. Sci. Med. Sci. 68(12), 1493-501, (2013)

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A quantitative study of the influence of inhaled compounds on their concentrations in exhaled breath. Spaněl P, Dryahina K, and Smith D J. Breath Res. 7(1), 017106, (2013)

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Explaining the non-newtonian character of aggregating monoclonal antibody solutions using small-angle neutron scattering. Castellanos MM, Pathak JA, Leach W, et al. Biophys. J. 107(2), 469-76, (2014)

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Parkinson's disease: increased motor network activity in the absence of movement. Ko JH, Mure H, Tang CC, et al. J. Neurosci. 33(10), 4540-9, (2013)

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Dynamics of isolated water molecules in a sea of ions in a room temperature ionic liquid. Wong DB, Giammanco CH, Fenn EE, et al. J. Phys. Chem. B 117(2), 623-35, (2013)

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Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting hypoxia inducible factor. Hangasky JA, Saban E, and Knapp MJ Biochemistry 52(9), 1594-602, (2013)

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Fluorescence of tryptophan in designed hairpin and Trp-cage miniproteins: measurements of fluorescence yields and calculations by quantum mechanical molecular dynamics simulations. McMillan AW, Kier BL, Shu I, et al. J. Phys. Chem. B 117(6), 1790-809, (2013)

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Formation of mono- and bis-Michael adducts by the reaction of nucleophilic amino acids with hydroxymethylvinyl ketone, a reactive metabolite of 1,3-butadiene. Barshteyn N Chem. Res. Toxicol. 22(5), 918-25, (2009)

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Protein structure and interactions in the solid state studied by small-angle neutron scattering. Curtis JE, McAuley A, Nanda H, et al. Faraday Discuss. 158, 285-99; discussion 351-70, (2012)

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Toxicity of irradiated advanced heavy water reactor fuels. Priest ND, Richardson RB, and Edwards GW Health Phys. 104(2), 195-210, (2013)

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²H enrichment distribution of hepatic glycogen from ²H₂O reveals the contribution of dietary fructose to glycogen synthesis. Delgado TC, Martins FO, Carvalho F, et al. Am. J. Physiol. Endocrinol. Metab. 304(4), E384-91, (2013)

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Characteristics of hydration water around hen egg lysozyme as the protein model in aqueous solution. FTIR spectroscopy and molecular dynamics simulation. Panuszko A, Wojciechowski M, Bruździak P, et al. Phys. Chem. Chem. Phys. 14(45), 15765-73, (2012)

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Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses. Dyson A, Ekbal N, Stotz M, et al. Br. J. Anaesth. 113(4), 708-16, (2014)

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Neutral carotenoid radicals in photoprotection of wild-type Arabidopsis thaliana. Magyar A, Bowman MK, Molnár P, et al. J. Phys. Chem. B 117(8), 2239-46, (2013)

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Depletion induced clustering in mixtures of colloidal spheres and fd-virus. Guu D, Dhont JK, Vliegenthart GA, et al. J. Phys. Condens. Matter 24(46), 464101, (2012)

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A large solvent isotope effect on protein association thermodynamics. Eginton C and Beckett D Biochemistry 52(38), 6595-600, (2013)

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Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. Bollyky JB, Long SA, Fitch M, et al. Clin. Exp. Immunol. 172(3), 363-74, (2013)

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Small organic solutes in sticky droplets from orb webs of the spider Zygiella atrica (Araneae; Araneidae): β-alaninamide is a novel and abundant component. Townley MA, Pu Q, Zercher CK, et al. Chem. Biodivers. 9(10), 2159-74, (2012)

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Air displacement plethysmography, dual-energy X-ray absorptiometry, and total body water to evaluate body composition in preschool-age children. Crook TA, Armbya N, Cleves MA, et al. J. Acad. Nutr. Diet. 112(12), 1993-8, (2012)

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Further evaluations of the toxicity of irradiated advanced heavy water reactor fuels. Edwards GW and Priest ND Health Phys. 107(5), 417-34, (2014)

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Merck 14,2940

Corp MSDS 1 (1), 4:B / FT-NMR 1 (3), 620:B / IR-Spectra (3), 1517:H / IR-Spectra (2), 1299:D / NMR-Reference 2 (1), 4:B / NMR-Reference 2 (1), 4:A / RegBook 1 (2), 2913:K / Sax 6, 873 / Structure Index 1, 463:B:6 / Vapor Phase 3, 1604:B

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